综合治疗非便秘型肠易激综合征临床研究  

Clinical study on physical and mental treatment of non-constipated irritable bowel syndrome

作　　者：李颖波 郭冰 

机构地区：[1]新乡市直机关医院,河南新乡453000

出　　处：《临床心身疾病杂志》2006年第5期332-333,共2页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨精神因素对非便秘型肠易激综合征的影响及心身综合治疗的疗效。方法采用症状自评量表对109例非便秘肠易激综合征患者与92名正常健康者进行评定分析,将症状自评量表评定总分>170分,阳性项>43.3,抑郁因子>1.71分的69名患者随机分为甲、乙两组治疗。甲组口服马来酸曲美布汀300mg·d-1·Tid,促均生2.25g·d-1·Tid;乙组在甲组治疗的基础上,联用抗抑郁剂+心理治疗。结果非便秘肠易激综合征患者与健康对照组比较,存在有较严重的抑郁、焦虑、恐怖状态及躯体化等多种情绪障碍(P<0.05或0.01)。治疗8w末,甲组躯体化、恐怖因子改善显著(P<0.05),乙组除偏执因子无显著改善外,其它各因子均有极显著性改善(P<0.01),两组间同期评分差异有显著性(P<0.05)。结论非便秘肠易激综合征发病与社会心理因素具有相关性,常规治疗联合抗抑郁剂+心理治疗可明显改善患者的临床症状。Objective To observe the relation of mental factor and non-constipated irritable bowel syndrome（IBS） and the curative effect of physical and mental combined therapy on IBS. Methods 109 patients with non-constipated IBS and 92 health persons was investigated with symptom check list-90（SCL-90）. 69 patients whose results of SCL-90 （ SCL〉170,the positive items are more than 43.3 and depressed factor are more than 1.71 ） were divided into two groups, the treatment group （34 cases ） were performed routine treatment combined antidepressant and psychotherapy and the control group （ 35 cases ） was only routine treatment. Results Compared with the healthy, the patients with non-constipated IBS had severe depression, anxiety, panic state and somatization. After 8 weeks treatment, the somatization and phobia factor of treatment group improved obviously, all factors except paranoid factor of the control group had significant improvement. There were significant difference between them at synchronization. Conclusion The non-constipated IBS has a close relationship with mental factor. Routine treatment combined antidepressant and psychotherapy can improve the patients＇ clinical symptom.

关 键 词：肠易激综合症 精神因素 抗抑郁剂 心理治疗 

分 类 号：R749.92[医药卫生—神经病学与精神病学]