非小细胞肺癌放疗靶区确定  

Target Volume Definition for Radiation Therapy of Non Small Cell Lung Cancer

作　　者：吴强[1] 肖光莉[1] 曹绍应 刘铮健 

机构地区：[1]澳门镜湖医院

出　　处：《华夏医药》2006年第4期270-273,共4页Hua-xia Medicine

摘　　要：根治性放射治疗对于局部进展及不能接受手术的非小细胞肺癌患者，治疗失败的主要原因为局部未控、复发和速处转移。三维适形放疗（3DCR7）和调强放疗（IMR7）是近年发展起来的放疗新技术，被广泛应用到肺癌的治疗，但还有很多问题有待解决，特别是在放射治疗靶区的确定方面还存在着很大争议。本文将通过有关文献的复习，对C7／MRI及正电子发射断层扫描（PE7）融合应用于靶区的确定，淋巴引流区的预防照射的需要性，摆位误差和呼吸运动等封靶区准确的影响及生物靶区的未来发展进行探讨；目的是帮助改善NSCLC的放疗治疗率并能提高患病的生存率。Patients with locally advanced, inoperable, non-small cell lung caner （NSCLC） have a poor prognosis mainly due to failure of local control, recurrence and the development of distant metastases after treatment with radical radiotherapy. Current techniques of 3-Dimensional Conformal Radiation Therapy （3D-CRT） and Intensity-Modulated Radiation Therapy （IMRT） are widely used in treatment of NSCLC, but there are many unsolved problems, especially, for different argument on the target volume definition. In this article, we review the integration of CT/MRI and PET imaging into target definition, omission of clinically uninvolved lymph-node areas, measure to decrease set-up and respiratory movement uncertaimies and future developmem of biological conformality are explored. The use of these new approaches may allow for improvemem in the therapeutic and overall survival rate of radiotherapy in NSCLC.

关 键 词：三维适形放疗 调强放疗 靶区的确定 生物靶区 

分 类 号：R734.2[医药卫生—肿瘤] R130.55[医药卫生—临床医学]