上皮性卵巢肿瘤患者血管内皮生长因子水平的检测  

Serum levels of vascular endothelial growth factor in epithelial ovarian neoplasm

作　　者：韩云志[1] 游言文[1] 陈四清[1] 田新红[1] 王玎玎[1] 刘旺根[1] 王琦[1] 王雪萍[1] 

机构地区：[1]河南中医学院解剖组胚学科,郑州450002

出　　处：《河南外科学杂志》2006年第6期1-2,共2页Henan Journal of Surgery

摘　　要：目的检测卵巢上皮性肿瘤患者血管内皮生长因子(VEGF)水平的变化,探讨其临床价值。方法采用酶联免疫吸附试验双抗体夹心法(ELISA)检测20例上皮性卵巢肿瘤、12例交界性上皮性卵巢肿瘤和48例上皮性卵巢癌患者血中VEGF水平。结果良性、交界性及恶性卵巢上皮肿瘤患者血VEGF水平依次升高分别为(686±150)、(750±90)和(1183±293)ng/L,P<0.01;血VEGF在浆液性卵巢腺癌、低分化卵巢腺癌中水平明显升高(P=0.046和P=0.029),而与临床分期无关。结论检测血VEGF水平有助于恶性卵巢上皮性肿瘤的术前诊断及估计预后。Objective To detect serum levels of vascular endothelial growth factor（VEGF） in epithelial ovarian neoplasm, and investigate the clinical means. Methods Serum levels of VEGF in 48 samples of ovarian carcinoma, 12 samples of borderline ovarian tumor, 20 samples of benign ovarian tumor was measured by Sandwich - ELISA. Results The serum levels of VEGF were increased in turn in benign ovarian tumor, borderline ovarian tumor and ovarian carcinoma, which were（686 ± 150） ng/ L, （750 ± 90） ng/ L and （ 1183 ± 293） ng/ L respectively （ P 〈 0.01 ） ; and the serum levels of VEGF were higher in serous cystadenocarcinoma and in poor differentiation, P =0. 046 and P = 0. 029 respect/vely. Conclusion The serum levels of VEGF could be seen as one of markers reflecting epithelial ovarian neophtsm tumor biological behavior, and assisted to diagnose and estimate offspring.

关 键 词：血管内皮生长因子 上皮性卵巢肿瘤 

分 类 号：R775[医药卫生—眼科] R737.31[医药卫生—临床医学]