胆碱能抗炎通路的研究进展  

Development of research on cholinergic anti-inflammatory pathway

作　　者：王博杰[1] 苏跃[1] 

机构地区：[1]北京结核病胸部肿瘤研究所麻醉科,101149

出　　处：《国际麻醉学与复苏杂志》2006年第4期242-245,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：Cholinergic anti-inflammatory pathway is a mechanism for neural inhibition of inflammation via the efferent vagus nerve. It can interact specifically with macrophage alpha7 subunits of nicotinic receptors, leading to cellular deactivation and inhibition of cytokine release. The pathway plays a critical role in controlling the systemic and local inflammations, and communicates with neuroendocrine pathways broadly. It constitutes a neural-immune circuit with the afferent vagus nerve whose activation can signal the brain that inflammation is occurring, bridging between the brain and the immune system.Cholinergic anti-inflammatory pathway is a mechanism for neural inhibition of inflammation via the efferent vagus nerve. It can interact specifically with macrophage alpha7 subunits of nicotinic receptors, leading to cellular deactivation and inhibition of cytokine release. The pathway plays a critical role in controlling the systemic and local inflammations, and communicates with neuroendocrine pathways broadly. It constitutes a neural-immune circuit with the afferent vagus nerve whose activation can signal the brain that inflammation is occurring, bridging between the brain and the immune system.

关 键 词：全身炎症反应综合征(SIRS) 胆碱能抗炎通路 宿主防御机制 感染因素 过度炎症反应 机体免疫 自身调节 病生理改变 炎症因子 细胞释放 

分 类 号：R363[医药卫生—病理学]