瘤内无水酒精注射治疗肝癌切除术后复发的疗效及预后因素分析  

Percutaneous Ethanol Injection for Postoperative Reccurent Tumor of Hepatocellular Carcinoma

作　　者：王志明[1] 任正刚[2] 陈漪[2] 葛宁灵[2] 干育红[2] 王艳红[2] 夏景林[2] 叶胜龙[2] 

机构地区：[1]复旦大学附属中山医院肿瘤中心化疗科,上海200032 [2]复旦大学附属中山医院肝肿瘤内科,上海200032

出　　处：《中国临床医学》2006年第4期589-590,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:研究经皮瘤内酒精注射(percutaneous ethanol inection,PEI)治疗原发性肝癌术后复发病灶的疗效,分析影响预后的因素。方法:原发性肝癌术后复发患者行PEI治疗,部分患者合用射频毁损治疗(radiofrequency ablation,RFA)、肝动脉化疗栓塞治疗(transcatheter arterial chemoembolization,TACE)。采用寿命表法分析患者复发后的生存期,并分析影响患者生存期的因素。结果:58例术后复发患者治疗后1、3、5年生存率分别为96.6％、59．2％、29．3％,中位生存期为42.5个月。单因素分析显示Child-Pugh分级B级为疗效差的影响因素,合用RFA有助于提高疗效;多因素分析显示Child-Pugh分级为独立的预后因素。结论:酒精注射冶疗复发性肝癌可取得较好疗效。Objective：To evaluate the survival and analyze prognostic factors of postoperative reccurent tumor of hepatocellular carcinoma （HCC） treated by percutaneous ethanol injection （PEI）. Methods：PEI （or combined with radiofrequency ablation （RFA） or transcatheter arterial chemoembolization （TACE） was performed in 58 patients who were diagnosed as reccurent le sions Life-table method was used for survival and prognostic factors were analysed. Results： The 1-, 3- and 5 year survival rates were 96. 6%, 59. 2%, 29. 3%, with a median survial of 42. 5 months. Univariate analysis indicated that Child-Pugh grade B was an important factor indicating a poor prognosis, the combination with RFA indicated a better prognosis. However,multivariate analysis showed that Child-Pugh grade was independent factor of prognosis Conclusion：PEI is effective in treating the postoperative reccurent tumor of hepatocellular carcinoma, especially in the patients with good liver function reserve.

关 键 词：原发性肝肿瘤 治疗 复发 无水酒精 预后 

分 类 号：R735.7[医药卫生—肿瘤]