伴混合的肌源性分化的皮肤间叶性错构瘤  

Cutaneous mesenchymal hamartoma with mixed myogenous differentiation

作　　者：Schrecengost J.E. Tabbara S. Patterson J. Wick M.R. 党倩丽 

机构地区：[1]OMS/Campus Box 800214, University of Virginia Medical Center, 2200 Jefferson Park Avenue, Charlottesville, VA 22908- 0214, United States Dr.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第8期8-9,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：A 3-month-old infant girl presented with a polypoid lesion in the perianal region. No changes in this lesion had been noted since birth. Microscopic examination of the excised specimen showed a mixture of mesenchymal elements, dominated by haphazard thin fascicles of skeletal muscle. Collagen and vascular changes were also apparent. Immunohistochemistry showed positive staining for muscle-specific actin and desmin in the fascicular components of the lesion, and smooth muscle actin, desmin, and h-caldesmon positivity in a haphazard collection of muscle fibers in the deep dermis and anal submucosa. Numerous Verhoeff-van Gieson positive elastic fibers were also noted. Hamartomas containing skeletal muscle have rarely been reported outside of the head and neck region. They must be distinguished from a variety of other tumors, including juvenile rhabdomyoma, benign Triton tumor, and rhabdomyosarcoma.A 3-month-old infant girl presented with a polypoid lesion in the perianal region. No changes in this lesion had been noted since birth. Microscopic examination of the excised specimen showed a mixture of mesenchymal elements, dominated by haphazard thin fascicles of skeletal muscle. Collagen and vascular changes were also apparent. Immunohistochemistry showed positive staining for muscle-specific actin and desmin in the fascicular components of the lesion, and smooth muscle actin, desmin, and h-caldesmon positivity in a haphazard collection of muscle fibers in the deep dermis and anal submucosa, Numerous Verhoeff-van Gieson positive elastic fibers were also noted. Hamartomas containing skeletal muscle have rarely been reported outside of the head and neck region. They must be distinguished from a variety of other tumors,

关 键 词：间叶性错构瘤 肌源性分化 平滑肌肌动蛋白 钙调蛋白结合蛋白 免疫组化染色 皮肤 肌纤维束 显微镜检查 骨骼肌 间质细胞 

分 类 号：R735.7[医药卫生—肿瘤] R738.7[医药卫生—临床医学]