HLA-C端粒端150kb区域与犹太人群银屑病相关  

The region of 150 kb telomeric to HLA-C is associated with psoriasis in the

作　　者：jewish population Martnez-Borra J. BrautbarC. González S. C. López-Larrea 朱国兴 

机构地区：[1]Department of Immunology, Hospital Universitario Central de Asturias, 33006 Oviedo, Spain

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第8期19-20,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：The HLA-Cw 0602 has been associated with psoriasis in different ethnic groups. But, it remains unclear whether HLA-C is the PSORS1 gene (the psoriasis gene in the MHC). Thus, several case-control studies have been performed in order to investigate whether HLA-C itself determines the susceptibility to the disease. We studied 59 Jewish patients with type I psoriasis and 79 matched controls. Polymorphic genes and markers from HLA-B (centromeric to HLA-C) to the corneodesmosin (CDSN) gene (telomeric to HLA-C) were genotyped in order to determine their contribution to the susceptibility to psoriasis. Neither HLA-Cw 0602 nor the allele CDSN TTC were significantly associated with psoriasis with the size of the sample studied. The genes and markers telomeric to HLA-C such as the microsatellite C1-4- 4 (OR = 2.6, 95% CI = 1.4- 4.7, Pc =0.018) the octamer transcription factor (OTF)- 3 gene (OR = 2.6, 95% CI = 1.6- 4.3, Pc = 0.0001) and the α -helix coiled-coil rod homologue (HCR) gene (OR = 2.5, 95% CI = 1.3- 4.5, Pc = 0.004), however, were associated with the disease. These results suggest that a major psoriasis susceptibility gene is likely to be located within a region of 150 kb telomeric to HLA-C and centromeric to the CDSN gene.The HLA-Cw ＊ 0602 has been associated with psoriasis in different ethnic groups. But, it remains unclear whether HLA-C is the PSORS1 gene （the psoriasis gene in the MHC） . Thus, several case-control studies have been performed in order to investigate whether HLA-C itself determines the susceptibility to the disease. We studied 59 Jewish patients with type I psoriasis and 79 matched controis. Polymorphic genes and markers from HLA-B （centromeric to HLA-C） to the corneodesmosin （CDSN） gene （telomeric to HLA-C） were genotyped in order to determine their contribution to the susceptibility to psoriasis. Neither HLA-Cw ＊ 0602 nor the allele CDSN ＊ TTC were significantly associated with psoriasis with the size of the sample studied. The genes and markers telomeric to HLA-C such as the microsatellite C1-4 - 4 （OR = 2.6, 95% CI = 1.4-4.7, Pc =0. 018） the octamer transcription factor （OTF）-3 gene （OR = 2.6, 95% CI = 1.6 - 4.3, Pc = 0. 0001） and the a-helix coiled-coil rod homologue （HCR） gene （OR = 2.5, 95% CI = 1.3- 4.5, Pc = 0. 004）, however,

关 键 词：种族人群 银屑病 HLA-Cw＊0602 端粒 病例对照研究 RS1基因 多态性基因 基因分型 等位基因 易感性 

分 类 号：R969.1[医药卫生—药理学] R758.63[医药卫生—药学]