皮肤镜检评估获得性黑色素细胞痣伴过度色素沉着离心性病灶(“Bolognia征”)的形态变化  

Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation (“Bolognia sign”)- assessed by dermoscopy

作　　者：Pizzichetta M.A. Massone C. Grandi G. 王琼 

机构地区：[1]Division of Medical Oncology C-Preventive Oncology, Centro di Riferimento Oncologico, Via Pedemontana Occidentale 12, I- 33081 Aviano, Italy Dr.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第8期25-26,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: Melanocytic nevi with eccentric foci of hyperpigmentation (“ Bolognia sign” ) can be considered as a melanoma-simulating type of acquired melanocytic nevus. We report on the morphologic changes of this type of melanocytic nevus over a 39-month period of dermoscopic follow-up. Observations: A 5-year-old girl had a 4-mm brown papule with a peripheral blue-black area on her right upper arm. The eccentric focus of the hyperpigmentation corresponded dermoscopically to a blue-gray area of pigmentation associated with irregular brown-black globules or dots and partially with a superficial black network. After 39 months, a globular type of acquired melanocytic nevus was detectable, which clinically and dermoscopically appeared to be completely benign. A nearly identical situation was observed in 5 other melanocytic nevi, underlining the involution of the pigmented foci in these nevi. The histopathologic diagnoses of 2 lesions were consistent with a compound type of acquired melanocytic nevus with eccentric foci of hyperpigmentation. Conclusions: Dermoscopy allows identification of a morphologic pathway of modifications, probably typical for this type of melanocytic nevus in children, and therefore enables avoidance of surgical excision with attendant hypertrophic scarring in children. Conversely, in adults, when dermoscopic follow-up of melanocytic nevi reveals eccentric foci of hyperpigmentation, surgical excision of the lesion is indicated.Melanocytic nevi with eccentric foci of hyperpigmentation （＂Bolognia sign＂） can be considered as a melanoma-simulating type of acquired melanocytic nevus. We report on the morphologic changes of this type of melanocytic nevus over a 39-month period of dermoscopic follow-up. Observations： A 5-year-old girl had a 4-ram brown papule with a peripheral blue-black area on her right upper arm. The eccentric focus of the hyperpigmentation corresponded dermoscopically to a blue-gray area of pigmentation associated with irregular brown-black globulas or dots and partially with a superficial black network. After 39 months, a globular type of acquired melanocytic nevus was detectable, which clinically and dermoscopically appeared to be completely benign. A nearly identical situation was observed in 5 other melanocytic nevi, underlining the involution of the pigmented foci in these nevi. The histopathologic diagnoses of 2 lesions were consistent with a compound type of acquired melanocytic nevus with eccentric loci of hyperpigmentation. Conclusions： Dermoscopy allows identification of a morphologic pathway of modifications, probably typical for this type of melanocytic nevus in children, and therefore enables avoidance of surgical excision with attendant hypertrophic scarring in children.

关 键 词：黑色素细胞痣 过度色素沉着 形态变化 离心性 获得性 经皮肤 病灶 镜检 组织病理学诊断 随访报道 

分 类 号：R739.5[医药卫生—肿瘤] R774.5[医药卫生—临床医学]