色素减少性蕈样肉芽肿的微小残留病变  

Minimal residual disease in hypopigmented mycosis fungoides

作　　者：Hsiao P.- F. Hsiao C.- H. Tsai T.- F. Jee S.- H. 李晓莉 

机构地区：[1]Dermatology, National Taiwan University College of Medicine, National Taiwan University Hospital,Taipei, Taiwan Dr.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第8期45-46,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：We describe the case of a 13-year-old boy with stage I hypopigmented mycosis fungoides in whom minimal residual disease was detected with T-cell receptor γ -polymerase chain reaction after the disease was in complete clinical remission. We further cloned and sequenced the T-cell receptor γ -polymerase chain reaction product of the lesion in remission and found that the original T-cell clone still existed in decreased amounts. The patient was followed up for 3 1/2 years without any new lesions developing. The clinical significance of this residual malignant T-cell clone in mycosis fungoides remains to be elucidated.We describe the case of a 13-year-old boy with stage I hypopigmented mycosis fungoides in whom minimal residual disease was detected with T-cell receptor γ-polymerase chain reaction after the disease was in complete clinical remission. We further cloned and sequenced the T-cell receptor γ-polymerase chain reaction product of the lesion in remission and found that the original T-cell clone still existed in decreased amounts. The patient was followed up for 3 1/2 years without any new lesions developing. The clinical significance of this residual malignant T-cell clone in mycosis fungoides remains to be elucidated.

关 键 词：微小残留病变 蕈样肉芽肿 减少性 色素 多聚酶联反应 T细胞受体Γ T细胞克隆 临床意义 完全缓解 反应产物 

分 类 号：R733.71[医药卫生—肿瘤] R739.5[医药卫生—临床医学]