异位性错构瘤性胸腺瘤:1例免疫组化研究的病例报道及文献回顾  

Ectopic hamartomatous thymoma: A case report with immunohistochemical study and review of the literature

作　　者：Kushida Y. Haba R. Kobayashi S. 吴佳纹 

机构地区：[1]Faculty of Medicine, Department of Diagnostic Pathology, Kagawa University, 1750- 1, Ikenobe, Miki-cho, Kita-gun, Kagawaken, 761- 0793, Japan

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第8期59-59,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Ectopic hamartomatous thymoma(EHT )is a rare benign tumor. We present a case of EHT, which was seen as subcutaneous mass on the left supraclavicular area in a 19-year-old man. The tumor consisted of spindle cells, epithelial cells, adipose cells, and a small amount of lymphocytes, as described previously. Immunohistochemically, spindle cells were positive for keratin, a-smooth muscle actin, CD34 and vimentin, but negative for desmin and S- 100 protein. Lymphocytes were positive for CD45RO but negative for CD20, CD1a, and CD99. Approximately, 5% of cells were positive for MIB-1 and no cells stained for p53 and bcl-2. Recognition of EHT is important and needs to be differentiated from high-grade sarcomas such as synovial sarcoma or glandular malignant peripheral nerve sheath tumor.Ectopic hamartomatous thymoma（EHT ） is a rare benign tumor. We present a case of EHT, which was seen as subcutaneous mass on the left supraclavicular area in a 19-year-old man. The tumor consisted of spindle cells, epithelial cells, adipose cells, and a small amount of lymphocytes, as described previously. Immunohistochemically, spindle cells were positive for keratin, a-smooth muscle actin, CD34 and vimentin, but negative for desmin and S-100 protein. Lymphocytes were positive for CD45RO but negative for CD20, CDla, and CD99. Approximately, 5% of cells were positive for MIB-1 and no cells stained for p53 and bcl-2. Recognition of EHT is important and needs to be differentiated from high-grade sarcomas such as synovial sarcoma or glandular malignant peripheral nerve sheath tumor.

关 键 词：免疫组化研究 文献回顾 错构瘤性 胸腺瘤 异位性 病例报道 A-平滑肌肌动蛋白 梭形细胞 S100蛋白 CD45RO 

分 类 号：R595.6[医药卫生—内科学] R696.1[医药卫生—临床医学]