Effects of levobupivacaine and bupivacaine on rat myometrium  

作　　者：LI Zi-gang ZHOU Liang TANG Hui-fang 

机构地区：[1]Department of Anesthesiology, Women＇s Hospital. School of Medicine, Zhejiang University , Hangzhou 310003. China [2]Zhejiang Respiratory Drugs Research Laboratory of State Food ＆ Drngs Administration of China, School of Medicine, Zhejiang Universisty, Hangzhou 310031. China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2006年第9期757-762,共6页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：Project (No. 2005038281) supported by the Postdoctor Foundationof China

摘　　要：Objective： To study the effect of levobupivacaine and bupivacaine on the contractility of isolated uterine muscle strips from pregnant and non-pregnant female rats. Methods： Full-thick myometrial strips were prepared from 18- to 2 l-day pregnant （n=8） and non-pregnant rats （n=7）. After contractions became regular, strips were exposed to cumulative concentrations of the two drugs from 10^-8 to 10^-4 mol/L, amplitude and frequency of the uterine contraction was recorded. Results： Two local anesthetics caused a concentration dependent inhibition on contractility of myometrial strips from pregnant and non-pregnant rats. In the myometrium from non-pregnant rats, -log/C50 of levobupivacaine and bupivacaine were 4.85 and 4.25 respectively. In the myometrium from pregnant rats, similar concentrations of levobupivacaine and bupivacaine were observed, -log/C50 were 2.7 and 2.9 respectively. Levobupivacaine produced an increase in amplitude of contractions, while bupivacaine showed an increased trend in frequency. Conclusion： These results demonstrate that levobupivacaine and bupivacaine may inhibit myometrium contractility. The inhibitory effect of levobupivacaine or bupivacaine is not enhanced by gestation in rat. Levobupivacaine may have more positive influence than bupivacaine in pregnant myometrium.Objective: To study the effect of levobupivacaine and bupivacaine on the contractility of isolated uterine muscle strips from pregnant and non-pregnant female rats. Methods: Full-thick myometrial strips were prepared from 18- to 21-day pregnant (n=8) and non-pregnant rats (n=7). After contractions became regular, strips were exposed to cumulative concentrations of the two drugs from 10?8 to 10?4 mol/L, amplitude and frequency of the uterine contraction was recorded. Results: Two local anesthetics caused a concentration dependent inhibition on contractility of myometrial strips from pregnant and non-pregnant rats. In the myometrium from non-pregnant rats, ?logIC50 of levobupivacaine and bupivacaine were 4.85 and 4.25 respectively. In the myo- metrium from pregnant rats, similar concentrations of levobupivacaine and bupivacaine were observed, ?logIC50 were 2.7 and 2.9 respectively. Levobupivacaine produced an increase in amplitude of contractions, while bupivacaine showed an increased trend in frequency. Conclusion: These results demonstrate that levobupivacaine and bupivacaine may inhibit myometrium contractility. The inhibitory effect of levobupivacaine or bupivacaine is not enhanced by gestation in rat. Levobupivacaine may have more positive influence than bupivacaine in pregnant myometrium.

关 键 词：LEVOBUPIVACAINE BUPIVACAINE MYOMETRIUM RAT 

分 类 号：R719[医药卫生—妇产科学] R96[医药卫生—临床医学]