Ang/Tie-2信号传导系统与视网膜微血管形成  

Ang/Tie signaling pathways and its effects on the vascularization of retinal capillaries

作　　者：左中夫[1] 刘学政[1] 

机构地区：[1]锦州医学院解剖学教研室,中国辽宁省锦州市121001

出　　处：《国际眼科杂志》2006年第4期857-859,共3页International Eye Science

基　　金：中国辽宁省优秀青年科研人才培养资金资助项目(No.3050007);中国辽宁省科技计划资助项目(No.2003225007)~~

摘　　要：促血管生成素(angiopoietins,Ang)及其受体Tie-2构成的Ang/Tie-2信号传导系统对于血管生成(angiogenesis)过程中血管成熟与稳定、调控血管完整性具有重要意义。该家族不同因子对于血管生成作用不同,而且同一因子对于血管生成的作用也随条件的不同而改变。对于生理和病理状态下的视网膜微血管形成,Ang/Tie-2信号传导系统起到调节血管结构的持久稳定性,调节渗漏的作用,这对于糖尿病视网膜病变(diabeticretinopathy,DR)的治疗提供了一个重要的思路。Angiopoietin family and its endothelium-specific tyrosine kinase receptor Tie-2 compose Ang/Tie signaling pathways, which plays essential roles in both vasculogenesis and angiogenesis, and certainly have effects on the vascularization of retinal capillaries. Recent findings with Ang/Tie signaling pathways suggested that its ability of anti-leakage and maintaining the integrity of endothelial monolayers may have great potential applications in clinical treatment of diabetic retinopathy.

关 键 词：促血管生成素 TIE-2 糖尿病视网膜病变 

分 类 号：R774.1[医药卫生—眼科]