钛网喉支架重建的动物实验研究  

Larygotracheal reconstruction using titanium mesh in canine model

作　　者：刘学奎[1] 曾宗渊[1] 田文栋[1] 于文斌[1] 陈福进[1] 

机构地区：[1]中山大学肿瘤防治中心头颈科,华南肿瘤学国家重点实验室,广东广州510060

出　　处：《现代肿瘤医学》2006年第9期1067-1069,共3页Journal of Modern Oncology

基　　金：广东省医学科学研究基金(A2003242)

摘　　要：目的:探讨应用钛网进行喉支架重建的可行性。方法:应用钛网在术中根据需要制作喉支架,选用健康成年杂种家犬6只行左侧垂直半喉切除术,保留甲状软骨外膜作为喉支架的衬里,带状肌覆盖钛网喉支架。结果:术后无感染,无呼吸困难。于术后3个月、6个月处死观察,钛网喉支架与其周边的甲状软骨结合稳固,无移位和排出。在光学显微镜下,3个月时,修复部位的喉腔、气管腔面见排列整齐的柱状纤毛上皮细胞。喉支架周围被薄层纤维组织包裹,可见轻微炎性反应,周围组织结构正常。6个月时,无炎性反应。结论:钛网喉支架的应用可避免喉气管腔狭窄,保证呼吸道畅通。Objective：To investigate the value of larygotracheal reconstruction using titanium mesh in Canine Model. Methods： Vertical hemilaryngectomy was performed in six healthy adult hybrid Canine. The larynx was reconstructed with the titanium mesh framework. Results： No signs of respiratory or wound infection and dyspnea were observed postoperatively. The animals were sacrificed at 3 and 6 month after surgery. The framework was firmly attached to the thyroid cartilages and surrounding tissues, without migration or extrusion. Histologic examination revealed： The larynx lumen reconstructed was covered with respiratory epithelium. The framework was surrounded by a layer of fibrous tissue, with a moderate inflammatory response and foreign body reaction at 3 month. There was no inflammatory response and foreign body reaction at 6 month. Conclusion： Stenosis could be avoided with the use of titanium mesh for larygotracheal reconstruction.

关 键 词：钛 喉支架 喉重建 

分 类 号：R739.65[医药卫生—肿瘤]