HPV检测与细胞学检查在宫颈癌前病变诊断中的比较  

Comparison of human papillomavirus testing and papanicolaou smears in primary screening for cervical intraepithelial neoplasia

作　　者：张燕玲[1] 万磊[1] 汪灿花[1] 李隆玉[1] 

机构地区：[1]江西省妇幼保健院肿瘤科,江西南昌330006

出　　处：《现代肿瘤医学》2006年第9期1126-1127,共2页Journal of Modern Oncology

摘　　要：目的:探讨人乳头瘤状病毒DNA检测与细胞学检查在宫颈癌前病变早期诊断中的比较。方法:病例来源于我院门诊及住院病人,均已在普通门诊做巴氏涂片(采用TBS细胞分类法)和高危型HPV-DNA检测,任何一项检查异常均在阴道镜下行多点活检。巴氏涂片以≥ASCUS/AGUS为阳性,HPV-DNA≥1.0pg/ml,宫颈活检病理作为金标准,以≥CIN2为阳性。结果:高危型HPV-DNA检测的敏感性为97.3%;特异性为71.6%;巴氏涂片的敏感性为62.2%;特异性为83.8%;两者相比高危型HPV-DNA检测方法有较高的敏感度和阴性预测值。结论:HPV-DNA检测在宫颈癌前病变早期诊断中的敏感度和阴性预测值都很高,是一种有效的初筛手段。Objective： To evaluate the accuracy of human papillomavirus （HPV） DNA testing for detecting cervical intraepithelial neoplasia （CIN）. Methods： Women from our hospital were screened using Papanieolaou （Pap） smears and HPV DNA testing by Hybrid Caputre （ HC - II）. Women who were positive for high - risk HPV or had Pap results of ASCUS or higher, were considered to have positive screening test results and referred for eolposeopy and biopsy. Rusults：The sensitivity of Pap （with a result of 〉1 ASCUS） for identifying women with CIN2 or higher was only 62.2% compared with 97.3% for HPV testing by HC -II. Differences in speeifieities were also observed： 83.8% for Pap and 71.6% for HC - II. Conclusion： Testing for HPV has higher sensitivity and predictive value of negative test. It is an effective screening method.

关 键 词：人乳头瘤状病毒 宫颈肿瘤 巴氏涂片 

分 类 号：R737.33[医药卫生—肿瘤]