中西药复方透析液对犬小肠粘膜超滤功能的影响  

Effects of copmpound dialysate of Chinese herbs and Western medicines on intestinal mucosa ultrafiltrative function in dogs

作　　者：黄德彬[1] 余昭芬[1] 

机构地区：[1]湖北民族学院医学院药理学教研室,湖北恩施445000

出　　处：《中国药理学通报》2006年第8期1005-1009,共5页Chinese Pharmacological Bulletin

基　　金：湖北省自然科学基金资助项目(No282005ABA197);湖北省卫生厅重点资助项目(No103JX1B121);湖北省教育重点资助项目(No052004D004);湖北民族学院资助项目(No15).

摘　　要：目的观察中西药复方透析液中对犬不同小肠段粘膜超滤功能的影响。方法随机将20只犬分为生理盐水组(NS)、对照组(CG)、川芎嗪低剂量组(lowerligustrazinedose,LLDG)和川芎嗪高剂量组(higherligustrazinedose,HLDG)。据肠系膜动静脉供血区对犬手术制作隔离空肠袢(jejunumloop,JL)、空回肠袢(jejunoileumloop,JIL)和回肠袢(ileumloop,IL),阻流双肾动脉,静脉输入高渗样品液[1,2],经肠袢口注入相应透析液,每隔30min收集肠袢液和相应系膜动静脉血,测定其水、电解质及UN、CR、UA,计算清除率和滤过率。结果各透析组水、电解质及UN、CR、UA清除率高于NS(P<0.01),LLDG高于HLDG和CG(P<0.05),而且空肠袢高于空回肠袢,空回肠袢又高于回肠袢(P<0.05)。结论低剂量川芎嗪加入到透析液中可增加肠袢对水、电解质及UN、CR、UA的超滤及透析效能,空肠袢透析效能最好。Aim To observe effects of compound dialysate of Chinese herbs and Western medicines on small intestinal mucosa uhrafihrative function in dogs Methods Twenty Beagle dogs were divided into 4 groups： NS, control （CG）, lower ligustrazine dose （LLDG） and higher ligustrazine dose group （HLDG）. According to the arteriovenous region of small intestine mesentery to make three isolation loops for comparative study, they were respectively jejunum loop （JL）, jejunoileum loop （JIL） and ileum loop （ IL）, and input hypersonic sample solution through vein after blocking the renal arteries to make the man -made renal failure models such as electrolytic Meanwhile, the dialysate was disorder, azotemia etc. perfused from the inlet of these isolation loops, respectively. Finally, these secretion of small intestine loops and blood samples which arteria and venae of the small intestine mesentery every 30 minutes were collected to determine the density of K ^＋ , Na^＋ , Cl^- , UN, CR, UA and the clearance and filtration rate in each group were calculated. Results The clearance rate and filtration rate in LLDG were remarkablely higher than that in the LHDG.the CG and the NS （P 〈0. 05 or P 〈0.01） , and the JL were remarkablely higher than the JIL and IL （ P 〈 0. 01 ）. Conclusion Low dose of Ligustrazine adding the dialysate increased uhrafiltration function and dialysis function of small intestine mucosa on K ^＋ , Na^＋ , Cl^-, UN, CR,UA, and the JL was best.

关 键 词：中西药复方透析液 小肠袢 超滤功能 

分 类 号：R-322[医药卫生] R289