32例胃癌前哨淋巴结术中定位和微转移灶检查分析  

The Analysis for Intra-operative Localization of Sentinel Lymph Node and Pathological Examination of Micro-metastatic focus in Treatment of 32 Cases with Gastric Cancer

作　　者：张军[1] 王子卫[1] 王严庆[1] 吴凯南[1] 杨红欣（校对） 

机构地区：[1]重庆医科大学附属第一医院普外科,重庆市400016 [2]不详

出　　处：《中国肿瘤临床》2006年第16期920-922,共3页Chinese Journal of Clinical Oncology

基　　金：重庆市卫生局基金项目资助(编号:04-2-129)

摘　　要：目的:探讨肿瘤前哨淋巴结(SLN)活检在胃癌术中应用的可行性。方法:将32例胃癌患者按肿瘤浸润深度分组,用术中注射专利蓝的方法定位前哨淋巴结,以细胞角蛋白(CK)免疫组织化学染色判断淋巴结转移情况。结果:32例患者全部检出SLN(100%)。出现淋巴结转移的有22例,其中SLN出现转移的有20例。SLN预测淋巴结癌转移的敏感性、假阴性率和准确率分别20/22(91%)、2/22(9%)和30/32(93.8%);胃癌T1组无SLN假阴性者,准确率6/6(100%);T2组无SLN假阴性者,准确率12/12(100%);T3组假阴性1例,准确率9/10(90%);T4组假阴性1例,准确率3/4(75%)。结论:采用肿瘤周围注射专利蓝的方法术中定位淋巴结是可行的SLN术中定位方法。To evaluate the feasibility for application of the sentinel lymph-node （SLN） biopsy in diagnosis and treatment of gastric cancer. Methods： Thirty-two patients with gastric cancer were divided into three groups （T1, T2, T3 and T4） based on extent of the tumorous invasion. SLN was localized using the method of patent-blue injection. Metastatic lymph nodes were detected by immuno- histochemical staining of cytokeratin （CK）. Results： The SLNs were detected in all 32 patients and the metastases of lymph nodes occurred in 22 cases, among which the metastasis of SLN were found in 20. The sensitivity, false-negative rate, and diagnostic accuracy of SLN for prediction of the lymph-node metastasis was 91%（20/22）, 9%（2/22） and 93.8%（30/32）, respectively. The diagnostic accuracy was 100% in the group with T1 cases, without false-negative cases, 100% in T2 cases without false-negative case, 90% in T3 with one false-negative case and 75% in T4 with one false-negative case. Conclusion： Application of the injection of patent blue tive localization of SLN. around tumor is a feasible method for intra-operative localization of SLN.

关 键 词：胃肿瘤 前哨淋巴结 专利蓝 

分 类 号：R735.2[医药卫生—肿瘤]