Contribution of genetics to a new vision in the understanding of inflammatory bowel disease  

作　　者：AS Pe■a 

机构地区：[1]Departments of Gastroenterology and Pathology,VU University Medical Centre, Amsterdam, The Netherlands

出　　处：《World Journal of Gastroenterology》2006年第30期4784-4787,共4页世界胃肠病学杂志（英文版）

摘　　要：Inflammatory bowel diseases （IBD）, such as Crohn＇s disease （CD） and ulcerative colitis （UC）, are chronic inflammatory autoimmune conditions of the gastrointestinal tract. Other organs, such as the eyes, skin and articulations, are often affected and IBD may be accompanied by other diseases of autoimmune origin. There is no single etiological factor responsible for the onset of IBD. Recent advances in genetics and in the molecular mechanisms of the proteins coded by these genes have given rise to a new vision in understanding these complex diseases. Activation of specific genes that affect antigen presentation and the handling of cells by innate immunity may lead to autoimmunity with the consequent activation of the major histocompatibility complex （MHC） and multiple cytokines involved in the regulation of acquired immunity. In this review IBD is described as a constellation of diseases that can best be classified as barrier diseases. This vision, developed by Kiel in Germany, includes the idea that changes in our environment due to the westernization of civilization have not been met with adaptation of the innate immune system, and this has given rise to autoimmune diseases. These diseases affect 1-5 of 1000 individuals and represent a major burden on the national health systems of many countries on different continents. On a world scale, a major challenge is to generate interventions to prevent the development of these diseases in Asia, Latin America and Africa.煽动性的肠疾病(IBD ) 例如 Crohn 的疾病(CD ) 和 ulcerative (UC ) ，是胃肠道的长期的煽动性的自体免疫的条件。另外的机关例如眼睛，皮肤和连接，经常被影响， IBD 可以被自体免疫的起源的另外的疾病伴随。没有为 IBD 的发作负责的单个病因学的因素。在遗传并且在这些基因编码的蛋白质的分子的机制的最近的进展在理解这些复杂疾病产生了新视觉。影响抗原表示并且由先天免疫处理房间的特定的基因的激活可以与主要组织适合性建筑群(MHC ) 的作为结果的激活导致汽车免疫，多重 cytokines 在后天免疫的规定包含。在这评论， IBD 被描述为能最好作为障碍疾病被分类的疾病的一个星座。这视觉，在德国由 Kiel 发展了，包括在我们的环境的变化没由于文明的 westernization 受到天生的免疫系统的改编，并且这产生了自体免疫的疾病的想法。这些疾病影响 1000 个个人的 1-5 并且在不同大陆上在许多国家的国家健康系统上代表主要负担。在世界规模上，主要挑战是产生干预在亚洲，拉丁美洲和非洲阻止这些疾病的发展。

关 键 词：Inflammatory bowel disease Crohn＇s disease Ulcerative colitis GENETICS AUTOIMMUNITY Major histocompatibility complex 

分 类 号：R574[医药卫生—消化系统]