细胞脑功能形态变异与肿瘤相关性  

Cell Brain Abnormalities in Carcinogenesis

作　　者：陈颖[1] 张楠[2] 孔庆忠[1] 

机构地区：[1]山东大学生命科学学院细胞脑研究中心,山东济南250100 [2]济南市中心医院肿瘤科,山东济南250100

出　　处：《癌症》2006年第9期1186-1190,共5页Chinese Journal of Cancer

摘　　要：肿瘤严重威胁人类的健康。但目前对其发病机理的认识仍不清楚。在所有与癌症发生机理相关的假说中,初现端倪的对传统癌发生理论已形成挑战的细胞脑理论正引起人们越来越多的关注。据细胞脑理论,由中心体、中心粒和微管组成的蛋白复合体在结构和功能上相当于人及动物的大脑,在细胞生物学行为中起着调控中枢的作用。本综述基于最新的研究成果,将进一步阐明以中心体为中心的细胞脑的异常与癌症发生之间的相互关系,从而为更好地认识癌症发生机理提供新的思路。这不仅有利于肿瘤的早期诊断和预防,同时为抗癌新药,特别是以细胞脑为靶点的药物的研发提供新的理论指导。Cancer seriously threatens the health of humans. The mechanism underlying the carcinogenesis, however, is unclear. Among all the related hypotheses, the lately postulated ＇cell brain＇ theory, challenging the conventional theory that gene abnormalities are the major players in carcinogenesis, is catching more and more attentions. According to this theory, the complex composes of the centrosome, centrioles, and connecting microtubules, and acts as the commandeering center of a cell in the structures and functions, equals to the brains of human being and animals, centering all the cellular activities. As far as carcinogenesis is concerned, cancer was interpreted by this theory as a ＇brain illness＇ rather than a genetic disease. This article, based on the latest findings, reevaluated the roles of the composing parts of cell brain, discussed their correlations to cancer development, and further explored the mechanisms of carcinogenesis including hepatocarcinogenesis. It wilt contribute not only to improving cancer diagnosis and prevention but also to the design of novel anticancer agents, particularly the centrosome/cell brain-targeting agents.

关 键 词：肿瘤/病理学 细胞脑 中心体 中心粒 微管 

分 类 号：R730.2[医药卫生—肿瘤]