胶原基纳米骨复合rhBMP-2及钛膜修复即刻钛种植体周围骨缺损  

Experimental Study of Instant Dental Implants by Nano-Hydroxyapatite/Collogen with rhBMP-2 and Titanium Membrance in Repairing Bone Defects

作　　者：刘冰[1] 陈鹏[1] 王忠义[1] 岳进[1] 毛天球[1] 

机构地区：[1]第四军医大学,陕西西安710032

出　　处：《稀有金属材料与工程》2006年第A02期331-334,共4页Rare Metal Materials and Engineering

基　　金：国家"973"基金资助项目(G1999054308)

摘　　要：观察胶原基纳米骨(nHAC)复合rhBMP-2及钛膜修复犬下颌骨拔牙创即刻钛种植体周围骨缺损的效果。其实验结果表明:①单纯nHAC组:术后6周已有新生骨小梁形成,术后12周修复骨缺损,钛种植体边缘可见较多新骨形成;②联合钛膜组:术后6周即见新生骨小梁沿钛膜生长,至术后12周,钛膜下骨密度更高,牙槽嵴顶较丰满;③复合rhBMP-2组:成骨过程较早,术后6周即有较多新生骨组织出现,术后12周新骨组织与宿主骨完全融合,并与种植体表面形成广泛的骨性结合。因此,nHAC具有良好的骨引导作用,可良好地修复种植体周骨缺损,复合rhBMP-2或／和钛膜后效果更佳。The effect of repairing bone defects of instant dental implant has been measured by using the nano-hydroxyapatite/collogen （nHAC） with rhBMP-2 and titanium membrance. The results show that all bone defects recovered normally： （1） nHAC group： new bone has formed at 6 week and repaired the defects of instant dental implants at 12 week, more new formed bone contacted to the surface of the implants and part of the material was absorbed; （2） rhBMP2 groups： new bone formed and combined with implant more early; （3） titanium membrance groups： more new trabecular bone formed along the titanium membrance. The alveolar ridges were chubbier than others. It is believed that the nHAC is a new bone grafting material in repairing bone defects of instant dental implant. The rhBMP-2 and titanium membrance are able to promote the osteogenersis around the implants and will be worth for clinical applications.

关 键 词：胶原基纳米骨 重组人骨形成蛋白-2 钛膜 种植体 骨缺损 

分 类 号：R783[医药卫生—口腔医学]