老年脑梗塞患者血浆内皮素水平的变化及意义  

Changes in plasma endothelin 1 levels in senile cerebral infarction and its clinical significance

作　　者：江卫[1] 王立祥 于正龙 邵福源 吴萍嘉 

机构地区：[1]第二军医大学附属长征医院神经内科

出　　处：《实用老年医学》1996年第5期215-216,共2页Practical Geriatrics

摘　　要：应用放射免疫分析法测定了４０例老年脑梗塞患者血浆内皮素（ＥＴ１）水平，并对另１０例缓慢进展型脑梗塞患者做了动态观察，结果发现老年脑梗塞患者血浆ＥＴ１水平显著高于对照组（Ｐ＜０．０１），并与病情轻重有关，其重度脑梗塞患者血浆ＥＴ１水平（１８．８±４．３ｐｇ／ｍｌ）明显高于轻、中度者（１５．３±３．６ｐｇ／ｍｌ），Ｐ＜０．０５；缓慢进展型脑梗塞患者血浆ＥＴ１水平随发病时间延长而递增，提示ＥＴ１可能是老年脑梗塞发病和进展过程的重要因素。Abstract Plasma endothelin 1 (ET 1) level was measured with radioimmunoassey in 40 patients with senile cerebral infarction and dynamic measurements were done in other 10 slowly progressive patients during different stages of the disease.The result showed that the plasma ET 1 level in the senile cerebral infarction was significantly higher than that in the control group.It was also related to the severity of the neurological disorder and its level in the severe subgroup (18.8±4.3pg/ml)was higher than that in the mild to moderate ones(15.3±3.6pg/ml, P <0.05).We also found that ET 1 level in the slowly progressive patients increased persistently after the onset of the disease. It is concluded that the plasma ET 1 level may take a deleterious role in the pathogenesis and outcome of cerebral infarction.

关 键 词：放射免疫分析 脑梗塞 血浆内皮素 老年人 

分 类 号：R743.33[医药卫生—神经病学与精神病学]