苦荞胚油对高脂血大鼠血脂及脂质过氧化作用的影响  

Cholesterol Lowering Effect of Tartary Buckwheat Germ Oil in Hypercholesterolemic Rat

作　　者：王敏[1] 魏益民[1] 高锦明[2] 

机构地区：[1]西北农林科技大学食品科学与工程学院,杨凌712100 [2]西北农林科技大学生命学院,杨凌712100

出　　处：《中国粮油学报》2006年第4期45-49,共5页Journal of the Chinese Cereals and Oils Association

基　　金：科技部攻关计划重大项目(2003BA901A19);西安市2003年农业科技攻关计划项目(NG200317)

摘　　要：目的:研究苦荞胚油对实验性高脂血症大鼠的降脂和抗氧化作用。方法:7w龄,60只W istar大鼠,按体重随机分为6组;除正常对照组外,其余各组用高脂饲料制作高脂血症动物模型,其中苦荞胚油分为0.2、0.5、1.0g/kg剂量组;以绞股兰总苷片为阳性对照组,剂量为0.032g/kg;正常组、模型组为10 mL/kg蒸馏水,各组每天灌胃一次,连续6周。最终测定血脂、肝脂和抗氧化相关指标。结果:与模型组相比,苦荞胚油各剂量组血清TG和肝脏MDA降低均达到极显著(P<0.01)水平;其中中剂量组降脂和抗氧化效果突出,其血清TC、血清MDA和肝脏TG降低均达到显著水平(P<0.05),肝脏TC降低达到非常显著水平(P<0.01)。结论:苦荞油有显著的降血脂、肝脂、抗肝脂氧化作用,对其降脂功能的利用应予以足够的重视。Objective： To study cholesterol -lowering effect by tartary buckwheat germ oil in hypercholester-olemic rat. Methods： 60 Wistar rats were divided randomly into 6 groups according to body weight. Except normal control group （ NC）, every group was hypercholesterolemic model. NC and high - fat control group （HFC） were given distilled water 10mL/kg; positive control group（PC） was given Gynostemma Pantaphyllum total glucoside tablet 0. 032 g/kg; tartary buckwheat germ oil was added with dosage of 0.2, 0.5, 1.0 g/kg respectively by gavage one time a day for 6 weeks. TG, TC, HDL - C, apoA1, apoB and MDA were detected respectively. Results： Compared with HFC, tartary buckwheat germ oil lowers serum TG（ P 〈0.01 ） and hepatic MDA（ P 〈0.01 ） in all groups. Medium dosage group has significant hypolipidemic effects ： serum TC decreased （ P 〈 0.05 ） , hepatic TG lowered （ P 〈 0.05）, hepatic TC lowered （ P 〈 0.01 ）, and plasma MDA lowered （ P 〈 0.05 ）. Conclusion ： tartary buckwheat germ oil exhibits significant lowering effects for serum lipids and hepatic lipids, and effect of antioxidation.

关 键 词：苦荞 油脂 血脂 肝脂 丙二醛 

分 类 号：TS218[轻工技术与工程—粮食、油脂及植物蛋白工程]