Synthesis of Potential Inhibitiors for Stat-3 Dimerization  

作　　者：崔家荣 简亚军 伍贻康 王少萌 

机构地区：[1]State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China [2]Department of Chemistry, Northwest University, Xi'an, Shaanxi 710069, China [3]Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, Ann Arbor, M148109, USA

出　　处：《Chinese Journal of Chemistry》2006年第9期1163-1169,共7页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos of Sciences （No. KGCX2-SW-209）. Dedicated to Professor Xikui Jiang on the occasion of his 80th birthday 20025207, 20272071, 20372075, 20321202） and the Chinese Academy

摘　　要：Nine bioactive ochromycinone analogues were synthesized through two different types of routes. Some unexpected products were obtained in the photo-induced oxidation. The syntheses disclosed herein complement those in the literature and offer inexpensive access to many of the known intermediates involved, most of which were studied years ago in completely different contexts.Nine bioactive ochromycinone analogues were synthesized through two different types of routes. Some unexpected products were obtained in the photo-induced oxidation. The syntheses disclosed herein complement those in the literature and offer inexpensive access to many of the known intermediates involved, most of which were studied years ago in completely different contexts.

关 键 词：INHIBITOR antitumor agent BENZYNE AROMATICS angucyclinone 

分 类 号：R979.1[医药卫生—药品]