自由基清除剂对大鼠实验性脑血管痉挛的脑血流调节作用  

Effect of radical scavenger on cerebral blood flow in cerebral vasospasm after experimental subarachnoid hemorrhage in rats

作　　者：滕伟禹[1] 田力[2] 隋韵声[3] 高岩[4] 张威[4] 

机构地区：[1]中国医科大学附属第一医院神经内科,辽宁沈阳110001 [2]中国医科大学附属第二医院老年病科 [3]沈阳市脑科医院神经内科 [4]中国医科大学附属第二医院神经内科

出　　处：《中国医科大学学报》2006年第3期242-243,共2页Journal of China Medical University

基　　金：辽宁省自然科学基金资助项目20052095

摘　　要：目的研究氧自由基清除剂超氧化物歧化酶(SOD)和羟自由基清除剂1,2-烟酰胺丙烷(AVS)对实验性大鼠蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)时脑血流量(CBF)的调节作用。方法采用枕大池注血法制作大鼠SAH模型,48h后经静脉方式分别持续给予SOD或AVS各1h,通过Laser-Doppler血流仪动态观察用药前后CBF的变化(%CBF)。结果与SAH组比较,SOD组CBF逐渐增加,至1h时为131.25±3.29(P<0.01);AVS组CBF无明显改变。结论SOD能够快速增加CVS时的CBF,AVS无类似作用。Objective： To investigate the effect of 2 radical scavengers, superoxide dismutase （SOD） and N, N＇-propylenedinicotinamide （AVS）, on the cerebral blood flow （CBF） in cerebral vasoplasm after subarachinoid hemorrhage （SAH） in rats. Methods： SAH rat models were established by injecting axillary artery blood into the cerebellomedullary cistern, and the rats were injected continuously and intravenously with SOD or AVS for 1 hour 48 hours after SAH. The changes of CBF （% CBF） were detected by laser Doppler blood apparatus. Results： CBF gradually increased and was 131.25 ± 3.29 at 1 hour after administration of SOD in SOD group, the increase was significant compared with SAH group （ P 〈0.01 ）. No CBF change was found in AVS group. Conclusion： SOD, not AVS, could increase CBF in cerebral vasospasm after SAH.

关 键 词：蛛网膜下腔出血 脑血管痉挛 自由基 脑血流量 超氧化物歧化酶 

分 类 号：R743.35[医药卫生—神经病学与精神病学]