NGF及其受体在涎腺腺样囊性癌中的表达及与神经周侵袭关系的探讨  

Expressions of nerve growth factor and its receptors in salivary adenoid cystic carcinoma and their relationship with perineural invasion

作　　者：尚德浩[1] 秦兴军[1] 孙长伏[1] 

机构地区：[1]中国医科大学附属口腔医院口腔颌面外科,辽宁沈阳110002

出　　处：《中国医科大学学报》2006年第3期277-278,F0002,共3页Journal of China Medical University

基　　金：辽宁省教育厅高等学校科研基金资助项目(20122147)

摘　　要：目的探讨涎腺腺样囊性癌(SACC)浸润性生长和神经周侵袭之间的关系。方法应用免疫组织化学方法检测21例涎腺腺样囊性癌及8例正常涎腺组织标本中神经生长因子(NGF)及其受体酪氨酸激酶(TrkA)和p75NTR的表达情况。结果正常涎腺组织的腺泡细胞中未见NGF,p75和TrkA阳性染色,在导管细胞中NGF75%阳性染色。在SACC肿瘤细胞胞浆中NGF81%阳性染色,p75NTR76%阳性染色,未见TrkA阳性染色。在癌周组织及神经纤维中发现NGF的阳性表达。NGF和p75NTR在腺样囊性癌的各病理分型中表达无明显差异。结论NGF和p75NTR的分泌在SACC肿瘤细胞的浸润性生长和神经周侵袭的过程中扮演重要的角色。Objective： To investigate the expressions of nerve growth factor （NGF） and its receptors, TrkA and p75NTR,in salivary adenoid cystic carcinoma （SACC） and their relationship with perineural invasion. Methods： The expressions of NGF, TrkA, and p75NTR in 21 cases of SACC and 8 normal salivary gland tissues were measured by using immunohistochemistry SABC method. Results： In normal salivary glands, no positive staining of NGF, TrkA, and p75NTR was found in the acinic cells, and the positive staining rate of NGF was 75% in ductal cells. In SACC, the positive staining rates of NGF and p75NTR were 81% and 76%, and no positive staining of TrkA was found. There was no significant difference in the expressions of NGF and p75NTR between SACC of different pathological types. Conclusion： NGF and p75NTR may play an important role in the infiltration and perineural invasion of SACC.

关 键 词：癌 腺样囊性 免疫组织化学 神经生长因子 酪氨酸激酶 P75NTR 

分 类 号：R782[医药卫生—口腔医学]