Fas/FasL在小细胞肺癌和转移淋巴结中的表达及临床意义  

Expressions of Fas and FasL and their clinical significance in small cell lung cancer and metastatic lymph nodes

作　　者：宿杰[1] 田大力[2] 陈东义[1] 张林[1] 孙丽华[3] 

机构地区：[1]中国医科大学附属第一医院胸外科,辽宁沈阳110001 [2]中国医科大学附属第四医院胸外科 [3]中国医科大学附属第一医院胸科实验室,辽宁沈阳110001

出　　处：《中国医科大学学报》2006年第3期282-283,共2页Journal of China Medical University

基　　金：国家自然科学基金资助项目(30170194);辽宁省教育厅高等学校科研基金资助项目(202013173)

摘　　要：目的检测Fas/FasL基因蛋白在小细胞肺癌(SCLC)及转移淋巴结中的表达,探讨其临床意义。方法应用免疫组化S-P法检测SCLC组织和转移淋巴结、正常无转移淋巴结及癌旁正常肺组织中Fas/FasL基因蛋白的表达情况。结果Fas在正常肺组织中表达强度(64.0%)明显高于SCLC组织(14.6%)(P<0.01);FasL在SCLC中表达强度(60.0%)明显高于正常肺组织(16.0%)(P<0.01);Fas在有转移淋巴结组织中表达强度(17.6%)明显低于无转移淋巴结组织(52.4%)(P<0.01);FasL在有转移淋巴结组织中表达强度(55.9%)明显高于正常无转移淋巴结组织(28.6%)(P<0.05);Fas/FasL在SCLC病理亚型、年龄、性别中的表达无显著差异(P>0.05)。结论Fas/FasL基因蛋白可能参与了小细胞肺癌的发生与发展,与小细胞肺癌的转移可能相关。Objective： To study the expressions of Fas and FasL and their clinical significance in small cell lung cancer （SCLC） and metastatic lymph nodes. Methods： The expressions of Fas and FasL were detected in 55 cases of SCLC, including 34 cases with lymph node metastasis and 21 without lymph node metastasis, and 25 normal lung tissues by S-P immunohistochemical method. Results： The positive expression rate of Fas in SCLC was significantly lower than that in normal lung tissues （ 14.6% vs. 64.0%, P 〈0.01 ）, while the positive expression rate of FasL in SCLC was significantly higher （60.0% vs. 16.0% , P 〈0.01 ）. The positive expression rate of Fas in SCLC with lymph node metastasis was significantly lower than that in SCLC without lymph node metastasis （ 17.6% vs. 52.4%, P 〈0.01 ）, while the positive expression rate of FasL in SCLC with lymph node metastasis was significantly higher （55.9% vs. 28.6%, P 〈0.05）. No significant difference in the positive expression rates of Fas and FasL was found between SCLC of different pathological types, between SCLC patients of different ages, and between male and female SCLC patients （ P 〉 0.05）. Conclusion： Fas and FasL may be involved in the occurrence, development, and metastasis of SCLC.

关 键 词：小细胞肺癌 Fas/FasL基因蛋白 

分 类 号：R734.2[医药卫生—肿瘤]