血清CA125在卵巢上皮性癌中的临床意义  

Clinical significance of serum CA125 in patients with epithelial ovarian carcinoma

作　　者：黄立[1] 白力伟 冯艳霞 姚嘉斐[1] 

机构地区：[1]中国医科大学附属第一医院妇科,辽宁沈阳110001 [2]秦皇岛市妇幼保健院妇产科

出　　处：《中国医科大学学报》2006年第3期306-307,共2页Journal of China Medical University

摘　　要：目的探讨血清CA125在卵巢上皮性癌中的预后价值。方法采用回顾性分析方法,对2000年1月至2003年5月本科收治的60例卵巢上皮性癌患者手术前后血清CA125水平,及其结合病理、临床分期及预后等临床资料进行分析。结果术前血清CA125水平与组织类型和临床分期相关(P<0.05),术后CA125半衰期>20d的复发率高于≤20d者(P<0.05);多因素分析表明,临床分期和CA125半衰期对预后有影响。术后CA125水平的升高可预测复发。结论卵巢上皮性癌患者术前测定血清CA125水平可初步判断组织类型及临床分期,术后监测血清CA125水平可及时发现复发,并可判断预后。Objective： To explore the prognostic value of the serum CA125 in patients with epithelial ovarian carcinoma. Methods： The clinical data, including serum CA125 level, histopathological type, FIGO stage, and prognosis, of 60 patients with epithelial ovarian carcinoma who underwent surgery between January 2000 and May 2003 were collected and retrospectively analyzed. Results： The serum CA125 level before surgery was related to histopathological type and FIGO stage （ P 〈 0.05）. The recurrence rate in patients with CA125 haft-life 〉20 days was higher than that in patients with CA125 halflife ≤ 20 days （ P 〈 0.05）. Muhifactor analysis showed FIGO stage and CA125 haft-life were factors affecting prognostic. The increase of serum CA125 level after surgery usually indicated the recurrence. Conclusion： The detection of serum CA125 level before surgery may help to judge the histopahthological type and FIGO stage of epithelial ovarian carcinoma. This marker is useful in early detection of recurrence and predicting prognosis.

关 键 词：血清CA125 半衰期 卵巢上皮性癌 预后 

分 类 号：R737.3[医药卫生—肿瘤]