E-选择素与心肌缺血再灌注损伤  

E-Selectin and Ischemia-Reperfusion Injury in the Heart

作　　者：董村南[1] 刘跃春[1] 

机构地区：[1]潍坊医学院,山东潍坊261042

出　　处：《心血管病学进展》2006年第5期637-639,共3页Advances in Cardiovascular Diseases

摘　　要：E-选择素是血管内皮细胞合成的一种糖蛋白分子,介导白细胞与内皮细胞的黏附过程,与炎症或缺血再灌注损伤时白细胞的募集有关。心肌缺血再灌注损伤时E-选择素表达明显增加,降低E选-择素的表达或阻断其作用可减轻缺血再灌注损伤。E-selectin is a kind of glycoprotein expressed in the vascular endothelial cell. E-selectin may play an important role in the adhesion of leukocytes to the vascular endothelium and is related to the recruitment of leukocytes during ischemia-reperfusion injury in the heart. The expression of E-selectin can be increased significantly during ischemia-reperfusion injury. A protective effect can be obtained by blocking the expression of ligands of E-selectin.

关 键 词：E-选择素 心肌缺血再灌注损伤 

分 类 号：R363[医药卫生—病理学]