大肠癌疫苗的最新进展  

Perspectives of Colorectal Cancer Vaccines

作　　者：王莉[1] 郭爱林 

机构地区：[1]第四军医大学西京医院消化内科,西安710033 [2]中国人民解放军第八一医院全军肿瘤中心内科

出　　处：《国际免疫学杂志》2006年第5期326-330,共5页International Journal of Immunology

基　　金：国家自然科学基金资助(No.30100218)

摘　　要：在寻求针对大肠癌的新疗法过程中,肿瘤疫苗因其具有低毒高特异性的特点给肿瘤治疗带来新的希望。大量的临床前期及临床实验证实,该方法通过多种主动特异性免疫治疗,激活特定的免疫系统并杀死体内肿瘤细胞。在这项研究工作中,我们概括了肿瘤疫苗的主要原则及研究结果,探讨最新的临床前期大肠癌免疫治疗方案,并有望提高这种生物治疗途径的效率。In the search for novel therapeutic approaches to treat patients with colorectal carcinoma, anticancer vaccination holds promise. Many preclinical and clinical evidence has demonstrated that the immune system can be polarized against malignant cells by means of several active specific immunotherapy strategies. The principles and the main results of cancer vaccine strategies so far implemented for the treatment of patients with colorectal carcinoma had been summerized in this work. We also discussed the most recent preclinical colorectal tumor immunology therapeutic schemes that might change the way to design the next generation of cancer vaccines, and improve the effectiveness of such a biotherapeutic approach.

关 键 词：抗原递呈细胞 主动特异性免疫治疗 细胞毒性T淋巴细胞 树突状细胞 辅助T淋巴细胞 热休克蛋白 肿瘤相关抗原 

分 类 号：R735.34[医药卫生—肿瘤] R392[医药卫生—临床医学]