CD_(44)在肝细胞癌及癌周组织中的表达及其意义  

Expression of CD_(44) in hepatocellular carcinoma and adjacent tissues and Its significances

作　　者：苏进根 朱上林[2] 肖家诚[3] 王天翔[2] 项明[2] 

机构地区：[1]上海市嘉定区中心医院普外科,201800 [2]上海第二医科大学瑞金医院普外科 [3]上海第二医科大学瑞金医院病理科

出　　处：《肿瘤研究与临床》2006年第9期612-614,共3页Cancer Research and Clinic

摘　　要：目的研究CD44s及CD44v6蛋白在人肝细胞癌(HCC)组织中表达及其意义。方法应用免疫组化方法检测42例HCC及其癌周组织与10例正常肝组织标本的CD44s及CD44v6表达情况。结果CD44s及CD44v6在肝癌组织中表达明显高于癌周及正常肝组织,与门静脉内癌栓、包膜浸润及分化程度密切相关(分别为P<0.01,P<0.05,P<0.05)。生存时间2年及2年以上组CD44s及CD44v6阳性表达分别为17.6%(/317),5.8%(/117),生存时间短于2年分别为52.6%(1/019),42.2%(/819)(P<0.05)。结论HCC组织中CD44的表达与细胞分化、浸润转移密切相关,其阳性表达有助于判断预后。Objective To investigate the expression of CD44 protein in hepatocellular carcinoma and clinical significances. Methods Immunohistochemistry was performed to examined 42 cases with hepatocellular carcinoma （HCC） and adjacent tissues and 10 cases of normal liver tissues for expression of CD44a and its isoforms CD44v6 proteins. Results Expression of CD44a and CD44v6 were all significantly higher in HCC tissues than it＇s surrounding liver and normal control, furthermore, be significantly correlated with the portal vein tumorous emboli, histological capsular infiltration and differentiation degree （P 〈 0.01, P 〈 0.05, P 〈 0.05, respectively）. The positive expression of CD44a and CD44v6 were 17.6 %, 5.8 % respectively in groups that survival time was longer than or equal to two years, while 52.6 %, 42.2 % respectively less than two years （P 〈 0.05）. Conclusion Expression of CD44a and CD44v6 is significantly correlated with differentiation, invasion and metastasis of HCC, and it is helpful to judge prognosis.

关 键 词：CD44a CD44V6蛋白 人肝细胞癌 

分 类 号：R735.7[医药卫生—肿瘤]