基质金属蛋白酶-9在自发性脑出血后的动态表达及其意义研究  

Temporal profile of matrix metalloproteinase-9 after spontaneous intracerebral hemorrhage and the relationship to clinical outcome

作　　者：张国华[1] 王珊[1] 史福平[1] 刘一鸥[1] 邸卫英[1] 

机构地区：[1]河北医科大学第二医院神经内科,河北石家庄050000

出　　处：《中国急救医学》2006年第9期641-643,共3页Chinese Journal of Critical Care Medicine

基　　金：河北省自然科学基金资助项目(No.C2005000748)

摘　　要：目的研究脑出血后血清基质金属蛋白酶-9(MMP-9)的动态表达及其与水肿体积和预后的关系,并探讨其潜在机制。方法应用ELISA法对30例脑出血患者血清MMP-9进行动态检测,用免疫比浊法测C反应蛋白水平,并与CT所示血肿周围水肿体积(PHE)和神经功能评分进行相关分析。结果脑出血组血清中MMP-9水平在发病后24 h显著增加,于第3天达高峰,持续至第7天后明显下降,24 hMMP-9水平与CT所示出血灶周围水肿体积和急性期病情变化密切相关。结论自发性幕上脑出血后血清MMP-9水平增高,血清MMP-9可能成为早期反映脑出血患者血肿周围水肿严重程度和预后的指标。Objective To study the temporal profile of MMP- 9 after spontaneous intracerebral hemorrhage and the relationship to the perihematomal edema volume（ PHE ） and clinical outcome. Methods MMP -9 was determined by enzyme - linked immunosorbent assays （ ELISA ） in 30 patients with intracerebral hemorrhage. C - reactive protein was determined by immunoturbidimetry. The relationship between the MMP- 9 and the perihematomal edema volume according to cranial CT scan and neurological assessment was investigated. Results The serum level of MMP - 9 was increased at 24 hours, the highest level of MMP - 9 was found at 3 days, and after 7days MMP - 9 level was decreased dramatically. MMP - 9 level at 24 hours was positively correlated with PHE and the disease. Conclusion Serum MMP - 9 level increased after deep intracerebral hemorrhage may be the index of predicting the severity of PHE and clinical outcome.

关 键 词：基质金属蛋白酶-9 脑出血 脑水肿 

分 类 号：R743.3[医药卫生—神经病学与精神病学]