病理性瘢痕组织iNOS和5-HT表达及与其增生和痛痒的关系  

EXPRESSIONS OF iNOS AND 5-HT IN ABNORMAL SCAR TISSUE AND THEIR RELATIONSHIP WITH ITCHING AND PAIN

作　　者：陈振雨[1] 魏爱华[2] 张维娜[1] 匡瑞霞[1] 刘肃[1] 

机构地区：[1]青岛大学医学院附属医院整形美容科,山东青岛266003 [2]胜利油田中心医院皮肤科

出　　处：《青岛大学医学院学报》2006年第3期231-233,236,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的检测诱导型一氧化氮合酶(iNOS)、5-羟色胺(5-HT)在病理性瘢痕及正常皮肤组织中的表达,探讨其与病理性瘢痕增生及痛痒的关系。方法应用免疫组化技术对痛痒、非痛痒的病理性瘢痕和正常皮肤组织中iNOS、5-HT的表达及分布情况进行检测,并采用图像分析法对检测结果进行半定量分析。结果痛痒的瘢痕组织与正常皮肤组织相比,iNOS、5-HT的表达均显著升高(F=25.47、44.92,q=4.39、4.43,P<0.01);非痛痒的瘢痕组织与正常皮肤组织相比,iNOS表达显著升高(q=3.96,P<0.01),5-HT表达差异无显著性(q=2.64,P>0.05);痛痒的瘢痕组织与非痛痒的瘢痕组织相比,5-HT的表达显著升高(q=3.92,P<0.01),iNOS的表达差异无显著性(q=2.71,P>0.05)。结论iNOS可能与病理性瘢痕的形成有关,其增高可能促进瘢痕的增生;5-HT可能与病理性瘢痕的临床痛痒症状有关,其增高可能导致病理性瘢痕临床痛痒症状的发生。Objective To study the expressions of inducible nitric oxide synthase （iNOS） and 5 hydroxytryptamine （5 HT） in abnormal scar and normal skin and their relationship with the scar proliferation and itching or pain. Methods Immunohistoehemical method was adopted to detect iNOS and 5 HT in itching or painful scars and non itching or non-painful scars and normal skin tissues, the results were semi quantitatively analyzed by image analysis. Results Compared with normal skin, iNOS and 5 HT expression in itching or painful scars were significantly higher （F= non-itching or non painful scars was significantly higher （q= 3.96,P〈0.01） 25. 47,44 ,5 92;q=4.39,1.43 ;P〈0.01）, and iNOS in snodifference （q=2.64,P〉0.05）. In the itching or painful scars, 5 HT was significantly higher than in non itching or non-painful scars （q= 3.92,P〈0.01） ; no difference was noted in iNOS （q= 2. 71, P〉0.05）. Conclusion iNOS may correlate with the scarring, and higher expression of iNOS may contribute to it. 5 HT may correlate with the itching and painful symptoms of abnormaI scars, and higher expressions of it may induce the symptoms.

关 键 词：一氧化氮合酶 血清素 瘢痕 

分 类 号：R364.31[医药卫生—病理学]