脑卒中后预防性抗抑郁治疗对神经功能康复的影响  

THE INFLUENCE OF POST-STROKE PROPHYLACTIC ANTI-DEPRESSION TREATMENT ON NERVE FUNCTIONAL REHABILITATION

作　　者：温肇霞[1] 李晖[1] 

机构地区：[1]青岛大学医学院松山医院神经科,山东青岛266021

出　　处：《青岛大学医学院学报》2006年第3期253-254,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的 探讨预防性抗抑郁治疗对脑卒中后病人神经功能康复的影响。方法 将84例急性脑卒中病人随机分为氟西汀治疗组和对照组，两组病人均给予脑卒中的基础治疗及正规的康复治疗．治疗组在此基础上给予氟西汀20mg治疗，每日1次；对照组不给予任何抗抑郁药物，疗程8周。观察病人在治疗前、治疗后4、6、8周汉密尔顿抑郁量表（HAMI））评分、改良爱丁堡量表评分中认知、运动功能评分的变化情况。结果治疗组治疗后4、6、8周HAMD及改良爱丁堡量表认知、运动功能等评分与治疗前比较差异有极显著性（F=73．19～1222．39，q=3．16～75．77，P〈0．05）；治疗组与对照组治疗后各指标比较，差异有显著性（t=8．86～47．42，P〈0．05）。结论 急性脑卒中后预防性抗抑郁治疗能明显提高神经功能康复的疗效，改善病人的抑郁症状。Objective To explore the effects of prophylactic anti depression therapy on nerve functional rehabilitation after stroke. .Methods Eighty four patients with acute stroke were randomly divided into study group and control group. For study group, fluxetine 20 rag, once a day, in addition to routine treatment; for control group, only routine treatment was given, the course was eight weeks for both groups. HAMD, the cognition and motor function were evaluated before and after treatment. Results In the study group, the HAMD, cognition and motor function were significantly improved after treatment （F=73. 19- 1 222.39,q=3. 16-75.77.P〈0.05）. The differences between the two groups were significant in terms of the above items （t= 8.86-47.12,P〈0.05）. Conclusion Prophylactic anti depression with fluxetine can obviously promote the recovery of nerve function and relieve the depression.

关 键 词：脑出血 脑梗死 抑郁症 康复 治疗结果 

分 类 号：R743[医药卫生—神经病学与精神病学]