置管引流后卡铂腹腔灌注化疗联合EP方案治疗妇科恶性腹水48例疗效分析  

A Curative Analysis of 48 Cases with Gynecological Malignant Ascites

作　　者：陈惠容[1] 杨敏[1] 蒋荣[1] 古至洲 

机构地区：[1]峨眉山市人民医院,四川峨眉山614200 [2]攀枝花市攀钢总医院,四川攀枝花617023

出　　处：《肿瘤基础与临床》2006年第5期412-413,共2页journal of basic and clinical oncology

摘　　要：目的 观察置管引流后卡铂灌注化疗联合EP方案治疗妇科恶性腹水的临床近期疗效。方法 腹腔置入中心静脉导管，充分引流后，卡铂300-500mg腹腔灌注化疗，并联合EP方案行同步全身化疗，观察对腹水的控制、KPS评分及毒副作用。结果 经1—3次卡铂腹腔灌注和2-3周期EP方案化疗后，有效率70．8％。缓解期5—12周，中位缓解期8．7周。KPS评分上升至80分以上者占60．4％，以卵巢癌疗效较好。其中消化道反应Ⅱ-Ⅲ度，骨髓抑制Ⅱ-Ⅲ度，无一例出现肾功能损害、耳毒性。结论 置管引流后卡铂腹腔灌注化疗联合EP方案治疗妇科恶性腹水取得了较满意的效果，患者均能耐受，KPS评分均有不同程度升高，生存期得到延长，值得在基层医院推广使用。Objective To observe the closer clinical curative effects of controlling gynecological malignant ascites by EP chemotherapy combined with Carboplatin intraperitoneal chemotherapy after duct deposited. Methods First to channel off completely by intraperitoneal central catheter deposited; then Carboplatin intraperitoneal chemotherapy used by 300 - 500 mg associated with EP intravenous concurrent chemotherapy, and to observe the ascites controlling, KPS grading and toxic side-effects. Results After 1 - 3 times of Carboplatin intraperitoneal chemotherapy and EP chemotherapy with 2 - 3 periods, efficiency rate was 70.8 %. releasing period was 5 - 12 weeks, median releasing period was 8.7weeks. 60.4 % of patients＇ KPS grade ascended to more than 80. The curative effect of ovarian carcinoma better than others. There were Ⅱ - Ⅲ degree of digestive reaction and bone marrow depression. There wasn＇ t renal or ototoxic damages. Conclusions The satisfactory results of controlling gynecological malignant ascites were gained by EP chemotherapy combined with Carboplatin intraperitoneal chemotherapy after duct deposited. All of the side-effects were endurable. The KPS grading increased with variable degree, and the survival had prolonged. The way is worthy to be utilized broadly in primary hospitals.

关 键 词：卡铂 化疗 妇科恶性腹水 卵巢癌 

分 类 号：R730.53[医药卫生—肿瘤] R737.3[医药卫生—临床医学]