阿昔洛韦药物树脂的制备  

Preparation of acyclovir resins

作　　者：刘宏飞[1] 赵欣 彭博[1] 张志宏[1] 潘卫三[1] 

机构地区：[1]沈阳药科大学药学院,沈阳110016 [2]东北制药集团沈阳市第一制药厂,沈阳110023

出　　处：《中国新药杂志》2006年第17期1464-1467,共4页Chinese Journal of New Drugs

摘　　要：目的:制备阿昔洛韦药物树脂复合物并对影响因素(温度、流速、粒径、浓度)进行考察。方法:静态交换法和动态交换法。结果:静态制备的优化条件是温度25℃,药物浓度7 mg·mL-1,树脂粒径60—80μm;动态制备的优化条件是温度25℃,药物浓度7．5 mg·mL-1,树脂粒径100-120μm,流速2 mL·min-1。结论:难溶性药物阿昔洛韦可制成药物树脂,且采用静态交换法制备树脂较好。Objective： To optimize the preparation of acyclovir resins. Methods： Bath method and column method were utilized. Results： The preparation of acyclovir resins using the bath method were optimized with drug concentration of 7 mg·mL^-1 and resin particle size of 60 ～80μm at 25 ℃ ; by the column technique the optimal conditions were using drug concentration of 7.5 mg·mL^-1 and resin particle size of 100 ～ 120μm at 25 ℃ , and the efflux speed at 2 mL·min^-1. Conclusion： The bath method seemed superior over the column method to prepare acyclovir resins.

关 键 词：阿昔洛韦 离子交换树脂 静态交换制备法 动态交换制备法 

分 类 号：R978.7[医药卫生—药品] R943.41[医药卫生—药学]