烟草特有亚硝胺的致癌作用及其抑制  

Carcinogenicity and Its Inhibition of 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone, a Tobacco-Specific N-nitrosamine

作　　者：毛友安[1] 魏新亮[1] 刘巍[1] 

机构地区：[1]湖南常德卷烟厂技术中心,湖南常德415000

出　　处：《环境与健康杂志》2006年第5期468-471,共4页Journal of Environment and Health

基　　金：常德卷烟厂博士后基金资助(cybh001)

摘　　要：该文综述了烟草特有亚硝胺4-(N-亚硝基甲氨基)-1-(3-吡啶基)-1-丁酮(NNK)的致癌作用及其抑制方面的研究进展,羰基还原和α-羟基化是NNK代谢活化的主要途径,NNK致癌主要作用器官是肺,致癌可能性与个体有关。有机异硫氰酸盐是NNK致癌的强抑制剂。多食用十字花科蔬菜、多吃水果、多饮用绿茶和黑茶对吸烟者和被动吸烟者是有益的。The advancement of research work on the carcinogenicity and its inhibition of 4-（N-nitrosomethylamino）-1-（3-pyridyl）- 1-butanone （NNK）, a tobacco-specific N-nitrosamine, was reviewed in the present paper. Carbonyl reduction and α-hydroxylation were the major routes of NNK metabolic activation, the main target organ of NNK carcinogenicity was the lung and the carcinogenic probability related to the individual, organic isothiocyanates were the most potent inhibitors for NNK carcinogenicity. Eating more cruciferae vegetables and fruit and drinking more green and black tea would be helpful for smokers and passive smokers, Research about the nosogenesis and carcinogenicity and its inhibition of the harmful components in cigarette smoke should be further reinforced.

关 键 词：烟草烟污染 烟草特有亚硝胺 4-(N-亚硝基甲氨基)-1-(3-吡啶基)-1-丁酮 致癌作用 

分 类 号：R994.6[医药卫生—毒理学]