多电极射频联合肝动脉栓塞化疗治疗不能切除大肝癌的临床观察  

Treatment of Unresectable Large Primary Hepatocellular Carcinoma by Multi-Electrode Radiofrequency Ablation Combined with Transcatheter Hepatic Arterial Chemoembolization

作　　者：庞志刚[1] 刘超[1] 李风鸣[1] 苏子霞[1] 郑蔚[1] 王广田[1] 

机构地区：[1]郑州大学第二附属医院普通外科,郑州河南450014

出　　处：《中国误诊学杂志》2006年第17期3283-3285,共3页Chinese Journal of Misdiagnostics

摘　　要：目的：探讨多电极射频（RFA）联合肝动脉栓塞化疗（TACE）治疗不能切除大肝癌的临床价值。方法：对23例大肝癌患者的30个结节采用RFA及TACE治疗，肝癌结节大小5．3～12．0cm，平均6．4cm。结果：18例治疗前甲胎球蛋白（AFP）升高的患者，治疗后明显下降。6例治疗后再次活检，呈完全性坏死。1a存活73．7％（14／19），3例生存4a以上，1例至今存活达6a以上。结论：RFA联合TACE治疗不能切除的大肝癌是一种安全有效的治疗方法。Objective：To evaluate clinical efficacy of multi-electrode radiofrequency ablation（RFA） combined with transcatheter hepatic arterial chemoembolization（TACE） in treatment of unresectable large primary hepatocellular carcinoma. Methods： 23 patients, who had 30 large HCC nodules, 5.3 to 12. 0 cm in diameter with the mean size of 6.4 cm, were treated by RFA combine with TACE. Results：In 18 patients with elevated alpha-fetoprotein（AFP） level, the AFP level decreased in 15 patients after RFA and TACE. Repeated biopsies on 6 cases showed completely destruction. The 1-year survived rate was 73% （14/19）. In the patients alive,three ones continued to survive for more than four years ,one for more than six years. Conclusion..RFA combine with TACE is a safe and effective method in treatment of unresectable large primary hepatocellular carcinoma.

关 键 词：肝肿瘤/治疗 化学栓塞 治疗性 导管消融术 

分 类 号：R735.705[医药卫生—肿瘤]