利用质子MR波谱分析研究丛集性头痛患者的下丘脑代谢  

Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy

作　　者：Lodi R. Pierangeli G. Tonon C. 李青波(译) 

机构地区：[1]Dipartimento di Medicina Clinica e Biotecnologia Applicata D. Campanacci, Universitd di Bologna, Policlinico S. Orsola, Via Massarenti 9, 40138 Bologna, Italy [2]不详

出　　处：《世界核心医学期刊文摘（神经病学分册）》2006年第9期20-20,共1页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside-and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.The authors used ^1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache （CH） and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls （p 〈 0.01）. Dividing the patients into episodic CH outside-and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.

关 键 词：丛集性头痛 下丘脑 MR波谱分析 N-乙酰天门冬氨酸 脑代谢 质子 健康受试者 代谢状况 

分 类 号：R741.041[医药卫生—神经病学与精神病学]