酪氨酸酶的研究进展  

Tyrosinase:Recent Prospects

作　　者：陈清西[1] 宋康康[1] 

机构地区：[1]厦门大学生命科学学院细胞生物学与肿瘤细胞工程教育部重点实验室,福建厦门361005

出　　处：《厦门大学学报（自然科学版）》2006年第5期731-737,共7页Journal of Xiamen University：Natural Science

基　　金：国家自然科学基金(30570408);福建省重点科技项目(2004N002)资助

摘　　要：酪氨酸酶(EC 1.14.18.1)是一种含铜的氧化还原酶,它广泛存在于动植物和微生物中,与生物体合成色素直接相关.在人体中,它与色素障碍性疾病及恶性黑色素肿瘤的发生与治疗有关.因此对编码酪氨酸酶基因的结构、表达及其调控,以及酪氨酸酶的抑制剂和激活剂的研究,引起国内外的广泛重视.目前,对酪氨酸酶活性中心及其催化功能的研究比较透彻,但对酪氨酸酶蛋白的立体结构尚不清楚.Tyrosinase is a copper-containing enzyme,as known as polyphenol oxidase,which is widely distributed in microorganisms, plants and animals. In human being, tyrosinase is the key enzyme for melanin biosynthesis, and is associated with melanin hyperpigmentation such as melasma, freckles, ephelide,senile lentigines. Furthermore,the studies for tyrosinase including the structure, expression and regulation of coding tyrosinase gene, and the inhibitors and activators of tyrosinase, have been paid attention to in the world. As so far,the active site and catalyic capacity of tyrosinase have been studied intensively, however, the three-dimensional structure of tyrosinase has been unclear.

关 键 词：酪氨酸酶 黑色素 色素障碍性疾病 基因 活性中心 

分 类 号：Q356.1[生物学—遗传学]