肝X受体在体内胆固醇平衡中的作用  

The role of liver X receptors in the control of cholesterol homeostasis

作　　者：代小艳[1] 唐朝克[1] 

机构地区：[1]南华大学心血管病研究所,湖南衡阳421001

出　　处：《中国病理生理杂志》2006年第9期1854-1857,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.30470720)

摘　　要：[A Review] LXRs,LXRα and LXRβ are ligand-activated transcription factors that are members of the nuclear receptor superfamily.LXRs preferentially bind with their heterodimeric partner,retinoid X receptor(RXR),to LXR response elements to activate gene expression.Cellular and whole-body cholesterol homeostasis is maintained through a network of transcriptional programs.Liver X receptors regulate key aspects of cellular and whole-body sterol homeostasis,including cholesterol absorption,lipoprotein synthesis and remodeling,lipoprotein uptake by peripheral tissues,reverse cholesterol transport,and bile acid synthesis and absorption.This review focuses on the role of liver X receptors in the control of cholesterol homeostasis.LXRs, LXRα and LXRβ are ligand - activated transcription factors that are members of the nuclear receptor superfamily. LXRs preferentially bind with their heterodimeric partner, retinoid X receptor （RXR）, to LXR response elements to activate gene expression. Cellular and whole - body cholesterol homeostasis is maintained through a network of transcriptional programs. Liver X receptors regulate key aspects of cellular and whole - body sterol homeostasis, including cholesterol absorption, lipoprotein synthesis and remodeling, lipoprotein uptake by peripheral tissues, reverse cholesterol transport, and bile acid synthesis and absorption. This review focuses on the role of liver X receptors in the control of cholesterol homeostasis.

关 键 词：受体 肝X ATP结合匣式转运子 胆固醇 核受体 

分 类 号：R363[医药卫生—病理学]