细胞凋亡与凋亡诱导因子  

Apoptosis and apoptosis-inducing factor

作　　者：张闻多[1] 丁文惠[2] 

机构地区：[1]北京医院心内科,北京100730 [2]北京大学第一医院心内科,北京100034

出　　处：《中国病理生理杂志》2006年第9期1858-1862,共5页Chinese Journal of Pathophysiology

基　　金：首都医学发展科研基金资助(No. 2002 -2003)

摘　　要：[A Review] The process of apoptosis is very complex.Apoptosis-inducing factor(AIF)has the ability to induce apoptosis via a caspase-independent pathway.The mature AIF protein,a flavoprotein(prosthetic group:flavine adenine dinucleotide)is normally confined to the mitochondrial intermembrane space.AIF translocates through the outer mitochondrial membrane to the cytosol and to the nucleus.AIF induces nuclear chromatin condensation,as well as large scale(V50 kb)DNA fragmentation.AIF is a phyloge-netically old,bifunctional protein with an electron acceptor/donor(oxidoreductase)function and a second apoptogenic function and AIF acts in a caspase-independent fashion.The molecular mechanisms via which AIF induces apoptosis are discussed in this review.The process of apoptosis is very complex. Apoptosis - inducing factor （AIF） has the ability to induce apoptosis via a caspase - independent pathway. The mature AIF protein, a flavoprotein （ prosthetic group ： flavine adenine dinucleotide） is normally confined to the mitochondrial intermembrane space. AIF translocates through the outer mitochondrial membrane to the cytosol and to the nucleus. AIF induces nuclear chromatin condensation, as well as large scale （ VSO kb ） DNA fragmentation. AIF is a phyloge - netically old, bifunctional protein with an electron acceptor/donor （ oxidoreductase ） function and a second apoptogenic function and AIF acts in a caspase -independent fashion. The molecular mechanisms via which AIF induces apoptosis are discussed in this review.

关 键 词：细胞凋亡 凋亡诱导因子 

分 类 号：R363[医药卫生—病理学]