改良MAID方案动脉插管治疗晚期软组织肉瘤的疗效  

Curative Effect of Modified MAID Arterial Infusion Chemotherapy of Advanced Soft Tissue Saccoma

作　　者：黄韵红[1] 文小平[1] 王文玲[1] 胡云飞[1] 周石[1] 张灵[1] 张凤莉[1] 

机构地区：[1]贵阳医学院附属医院肿瘤科,贵阳市550004

出　　处：《中国肿瘤临床》2006年第17期1005-1007,共3页Chinese Journal of Clinical Oncology

摘　　要：目的:观察改良MAID方案[异环磷酰胺(IFO)/美斯钠(Mesna)+吡喃阿霉素(THP)+氮烯咪胺(DTIC)]经动脉局部插管持续灌注化疗在晚期软组织肉瘤中的客观疗效和毒性反应。方法:局部晚期或复发转移软组织肉瘤(softtissuesarcoma,STS)患者21例,所有患者化疗前均接受动脉插管,IFO6g/m2持续静脉灌注72小时,d1～3,Mesna10g/m2持续静脉灌注96h,d1～4,THP60mg/m2持续动脉灌注72h,d1～3,DTIC1000mg/m2持续静脉灌注72h,d1～3,q21～28d为一疗程。结果:全组21例患者总有效率为57.14%,CR1例,PR10例,中位缓解期4.9月。15例患者生存至今。主要毒性反应为骨髓抑制、消化道反应和脱发等。其他毒性反应还有静脉炎、食欲下降、乏力等。结论:动脉局部插管改良MAID方案持续灌注化疗在晚期软组织肉瘤中近期疗效较高,毒性反应较大,但无化疗毒性相关死亡病例,值得进一步临床观察。Object： To evaluate the efficacy and toxicity of modified MAID arterial infusion chemotherapy of advanced soft tissue sarcoma. Methods： All of 21 patients with advanced soft tissue sarcoma received regional selected arterial infusion chemotherapy with port system. They were treated by modified MAID （Pirarubicin 60mg/m^2 cia [continuous infusion arterial] 72h Dacarbazine 1000mg/m^2 cia 72h Ifosfamide 6000mg/m^2 civ [continuous infusion venous] 72h Mesna 10g/ m^2 civ 96h ） with a course of treatment of 21 to 28 days. Results： The overall effective rate was 57.14%, with a complete response in 1 case and partial response in anther 10 cases. The media remission was 4.9 months. Fifteen patients are still alive. On the other hand, the major toxicities included myelosuppression, gastrointestinal toxicity and alopecia. Other toxicities included fatigue, anorexia and phlebitis. Conclusion： The response rate of modified MAID arterial infusion for advanced soft tissue sarcoma was good efficacy and high toxicities and more prospective studies are needed.

关 键 词：软组织肉瘤 吡喃阿霉素 异环磷酰胺 氮烯咪胺 动脉插管化学治疗 

分 类 号：R738.6[医药卫生—肿瘤]