抑郁症患者血浆孤啡肽含量研究  

A study of the relation between orphanin FQ and depression

作　　者：王斌[1] 郑洪波[1] 秦峰[1] 胡文生[1] 黎娟花[1] 

机构地区：[1]广东省广州市精神病医院,510370

出　　处：《中华神经医学杂志》2006年第9期947-949,共3页Chinese Journal of Neuromedicine

摘　　要：目的为探讨抑郁症的可能病因,对抑郁症患者血浆孤啡肽(OFQ)含量进行了对照研究。方法抽取29例抑郁症患者和24例正常人的静脉血,用放射免疫(RIA)的方法分别测其血浆中OFQ含量,比较抑郁症患者和正常人血浆OFQ含量有无差异,抑郁症患者OFQ含量与汉密顿抑郁量表(HAMD)评分的相关性,及抑郁症患者血浆OFQ含量的影响因素。结果与正常人比较,抑郁症组OFQ含量明显升高(t=8．70,P＜0．0001)；OFQ含量与HAMD评分呈正相关(r=0．63,P＜0．01)；OFQ含量主要与抑郁情绪、夸大、失眠、自卑感、自杀、强迫症状、教育水平、关注身体健康等因素相关,而年龄、性别、职业、病程、曾用药等其他因素与OFQ含量无明显相关。结论通过测量血浆OFQ含量可作为抑郁症诊断的参考指标。Objective To search the causes of depression, and to study the relation between orphanin FQ （OFQ） and depression. Methods The level of plasma OFQ of 29 patients with depression （depression group） and 24 healthy volunteers （control group） were measured and compared by radioimmunoassay （RIA）. In addition, the correlation between the plasma OFQ level and Hamilton rating scale for depression （HAMD） scores, and the influential factors of the level were studied and analyzed. Results The level of plasma OFQ in the depression group was higher than that of the control group, and the difference was statistically significant （t=8.70, P〈0.0001）. And the level of OFQ was positively correlated to HAMD （r=0.63, P〈0.01）. Many factors affected the OFQ level, including gloomy mood, exaggeration, insomnia, inferiority feeling, suicide, obsession and education, etc. While other factors like age, sex, occupation, course of disease, and medication do few effects on it. Conclusion The level of plasma OFQ can be used as a reference in the diagnosis of depression.

关 键 词：孤啡肽 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]