胃肠神经肽对肠黏膜免疫的调节  

Modulation of Gastrointestinal Neuropeptides on Gut Mucosal Immunity

作　　者：刘云芳[1] 陈耀星[1] 王子旭[1] 

机构地区：[1]中国农业大学动物医学院

出　　处：《解剖科学进展》2006年第3期259-262,266,共5页Progress of Anatomical Sciences

基　　金：国家自然科学基金资助项目(No.30471247)

摘　　要：肠神经和肠相关淋巴组织(GALT)的免疫细胞均能合成神经肽,目前肠道中已发现CGRP、VIP、SP等50多种神经肽。这些神经肽可以影响淋巴细胞的增殖、细胞因子和免疫球蛋白的合成,并能够调节其他一些免疫细胞的活性,同时淋巴细胞、巨噬细胞、肥大细胞等免疫细胞对神经肽具有产生应答的能力。Neuropeptides are synthesized by enteric nervers and the immune cells of gut-associated lymphoid tissue （GALT）. Presently, more than 50 sorts of neuropeptides have been found in gut such as CGRP, VIP,SP,etc. Neuropeptides can also affect lymphocyte proliferation, cytokine and immunoglubin synthesis, and modulate the activities of other immune cells. Furthermore, lymphocytes, macrophages and mast cells can response to neuropeptides.

关 键 词：胃肠神经肽 黏膜免疫 调节 淋巴细胞的增殖 肠相关淋巴组织 免疫细胞 免疫球蛋白 CGRP 

分 类 号：R574.620.2[医药卫生—消化系统]