肿瘤抑制基因甲基化与胃癌  

Relationship Between Methylation of Tumor Suppressor Gene and Gastric Cancer

作　　者：杨少辉[1] 戴冬秋[1] 

机构地区：[1]中国医科大学附属第一医院肿瘤外科,沈阳110001

出　　处：《中国普外基础与临床杂志》2006年第5期614-616,共3页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金项目(编号:30271477);教育部留学回国人员科研启动基金项目(编号:2002-247)

摘　　要：目的探讨肿瘤抑制基因甲基化与胃癌的关系。方法对近年来关于肿瘤抑制基因甲基化与胃癌关系的文献进行综述分析。结果胃癌中,细胞周期调控基因、有丝分裂检测点基因、凋亡相关基因、错配修复基因、转移相关基因等多种肿瘤抑制基因发生甲基化而失活。结论肿瘤抑制基因甲基化在胃癌的发生、发展过程中起重要作用,肿瘤抑制基因的甲基化有可能成为胃癌诊断、判断转移和评价预后的分子标记物,去甲基化干预有望成为胃癌治疗的新方法。Objective To investigate the relationship between methylation of tumor suppressor gene and gastric cancer. Methods The literatures in recent years about the concept of methylation, its biological significance and the relationship between DNA methylation/demethylation and gastric cancer were reviewed. The effects of methyla tion of different tumor suppressor genes on gastric cancer were also analyzed. Results The effect of aberrant methy lation on the development and the progression of gastric cancer was still unclear but it was supposed that the inactivation of genes related with cell cycle regulation, mitotic checkpoint, apoptosis, DNA mismatch repair, metastasis suppression and so on might be attributable to the aberrant methylation in gastric cancer. Conclusion Aberrant methylation of tumor suppressor genes plays an important role in the development and progression of gastric cancer. The status of methylation of tumor suppressor genes may be used as a useful molecule marker for diagnosis, assess ing metastasis and evaluating prognosis, and demethylation could possibly be a new therapy for gastric cancer.

关 键 词：胃癌 肿瘤抑制基因 甲基化 

分 类 号：R735.2[医药卫生—肿瘤] R730.231[医药卫生—临床医学]