介入动脉化疗治疗口腔颌面部鳞状细胞癌的疗效观察  

Effect of Interventional Artery Chemotherapy for Squamous Cell Carcinoma in Oral and Maxillofacial Region

作　　者：王巍[1] 李吉辰[1] 张斌[1] 范新东[2] 

机构地区：[1]哈尔滨医科大学口腔医学院口腔颌面外科,黑龙江哈尔滨150001 [2]上海市第九人民医院放射科,上海200070

出　　处：《口腔颌面外科杂志》2006年第3期229-231,共3页Journal of Oral and Maxillofacial Surgery

基　　金：黑龙江省自然科学基金(D2004-38);哈尔滨医科大学研究生创新资金

摘　　要：目的:探讨区域性动脉化疗治疗口腔颌面部鳞状细胞癌的可行性及有效性。方法:对15例病理诊断为口腔颌面部鳞状细胞癌的患者,超选择性直接动脉灌注顺铂进行化疗,观察术中反应及术后疗效,随访,评价治疗的可行性及有效性。结果:动脉化疗术中没有明显异常反应;动脉化疗的有效率为93.3%,肿瘤在化疗后当天或第2天,化疗局部疼痛和肿胀感缓解,口、鼻腔内出现分泌物或坏死组织脱落。15例中完全缓解(complete response,CR)5例,部分缓解(partial response,PR)9例,失访1例。结论:“介入动脉化疗”是治疗口腔颌面部鳞状细胞癌的有效手段之一,可以作为综合序列治疗的重要组成部分。Objective： To discuss the feasibility and effect of interventional artery chemotherapy for oromaxillo-facial region squamous cell carcinoma. Methods： 15 patients diagnosed as squamous cell carcinoma by pathological diagnosis, were carried out for direct arterial perfusion of cisplatin, and followed up. Feasibility and effects of the treatment were evaluated. Results： There was no obvious paradoxical reaction during the operation, and effective rate of chemotherapy was 93.3%. Local pain and engorgement were relieved in the first day or the second day post-treatment, ablated secretions and necrotic tissue appearanced at oral and nasal cavities. 5 cases appeared complete response, 9 cases appeared partial response and 1 lost to follow-up. Conclusion： Interventional artery chemotherapy is one of the effective method in treatment of squamous cell carcinoma in oromaxillo-facial region, and could be one of important part in synthetic sequence therapy.

关 键 词：介入动脉化疗 口腔 鳞状细胞癌 

分 类 号：R739.8[医药卫生—肿瘤]