前循环缺血性卒中老年患者颈动脉斑块及其稳定性与血流壁振荡切应力的关系  

Relationship about wall oscillatory shear stress and plaque in carotid artery in ischemic stroke

作　　者：贾伟华[1] 田桂玲[2] 周立春[1] 张天林[2] 

机构地区：[1]首都医科大学附属北京朝阳医院(京西院区)神经内科,北京100043 [2]天津医科大学总医院神经内科,天津300070

出　　处：《临床荟萃》2006年第20期1449-1451,共3页Clinical Focus

摘　　要：目的通过探讨前循环缺血性卒中老年患者颈总动脉分叉处血流壁振荡切应力的水平,分析其在颈动脉斑块形成过程中的影响。方法选择前循环缺血性卒中老年患者,应用经皮血管彩色多普勒超声测量颈动脉斑块及其稳定性,测量患侧颈动脉血流速度、血管内径和血液黏滞度,通过公式计算血流壁振荡切应力。结果血流壁振荡切应力在无斑块组(13.418±4.250)和有斑块组(18.052±6.880)dyn/cm2之间(P<0.01)、高回声斑块组(16.235±5.505)dyn/cm2和低回声斑块组(19.753±7.627)dyn/cm2之间(P<0.05)差别均有统计学意义。结论与平均血流切应力相比,高血流壁振荡切应力在颈动脉斑块,尤其是在预测不稳定斑块的形成中更有意义。Objective To analyze the relationship between vascular wall oscillatory shear stress and the plaque in carotid artery. Methods All the samples were from ischemic stroke in carotid artery. The plaque in carotid artery and its stability were measured by color Doppler uhrosound and the vascular oscillatory shear stress was calculated. Results As compared with the group without plaque, the wall oscillatory shear stress in group with plaque was higher （13. 418±4. 250） dynes/cm^2 vs （18. 052±6. 880） dyn/cm^2 （ P 〈0.01）. Similarly,the oscillatory shear stress in group with low-echo plaque was higher than that in hi-echo plaque （19. 753±7. 627） dyn/cm^2 vs （16. 235±5. 505） dyn/cm^2 （ P 〈0.05）. Conclusion The oscillatory wall shear stress has a significant influence on the plaque in carotid artery and its stability.

关 键 词：脑血管意外 颈动脉疾病 动脉硬化 超声检查 多普勒 彩色 

分 类 号：R743.1[医药卫生—神经病学与精神病学]