帕金森病患者左旋多巴治疗对血浆同型半胱氨酸的影响  

Effect of L-dopa on plasma homocysteine in elderly patients with Parkinson's disease

作　　者：王红梅[1] 葛许华[1] 周联生[1] 耿德勤[2] 

机构地区：[1]江苏省徐州市第一人民医院神经内科,221002 [2]徐州医学院附属医院神经内科

出　　处：《中华神经科杂志》2006年第9期609-611,共3页Chinese Journal of Neurology

摘　　要：目的探讨左旋多巴对帕金森病(Parkinson disease,PD)患者血浆同型半胱氨酸(Hcy)和维生素 B_(12)等的影响。方法分为 PD 组28例和健康对照组30名,测定被检者血浆中 Hcy和维生素 B_(12)浓度等,PD 组患者分别在左旋多巴治疗前、后测两次。结果 PD 组左旋多巴治疗后血Hcy 浓度[(19.19±8.01)μmol/L]明显高于治疗前[(12.50±3.78)μmoL/L]和健康对照组[(12.60±3.94)μmol/L],差异有统计学意义(P<0.01);经相关回归分析显示 PD 组左旋多巴治疗后血 Hcy 水平与维生素 B_(12)呈负相关(r=-0.386)。结论左旋多巴治疗可导致血浆中 Hcy 升高,有必要对服用左旋多巴的 PD 患者群进行 Hcy、维生素和叶酸的检测,补充维生素 B_(12)叶酸可能会降低 Hcy 和危险因素。Objective To explore the effect of L-dopa on plasma homocysteine and folic acid in patients with parkinsons＇ s disease （PD）. Methods Twenty eight elderly PD patients and thirty normal subjects were enrolled in this group. The homocysteine, cobalamin and folate were examined in normal group and in PD group before treatment and after being treated with L-dopa for six moths respectively. Then the homocysteine, cobalamin and folate were compared between the two groups. Results The plasma homocysteine levels increased in PD patient group after being treated with L-dopa for six months （ 19.19±8.01 ） μmol/L as compared with those of the PD group before treatment （ 12. 50±3.78） μmol/L and those of control group（ 12. 60±3.94 ） μmol/L （ P 〈 0. 01 ） . Correlation analysis found that plasma Hcy in PD patients treated with L-dopa was negatively correlated with cobalamin （r = - 0. 386）. Conclusions The treatment of L-dopa in PD patients can elevate the level of Hcy. Therefore, it is necessary for PD patients treated with L-dopa to examine homocysteine, cobalamin and folate. Supplement of cobalamin and folate could decrease the Hcv level and risk factors.

关 键 词：帕余森病 寿旋多巴 高半胱氨酸 维生素B12 叶酸 

分 类 号：R739.4[医药卫生—肿瘤]