采用骨内型牵张器建立垂直向牙槽骨牵张成骨动物模型  

An Experimental Animal Model for Vertical Alveolar Distraction Osteogenesis Using Intraosseous Distractors

作　　者：周苗[1] 陈松龄[1] 黄代营[1] 张继斌[1] 庾晓伟[2] 

机构地区：[1]中山大学附属第一医院口腔科,广东广州510080 [2]中山大学附属第二医院口腔科,广东广州510120

出　　处：《中山大学学报（医学科学版）》2006年第5期566-569,共4页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省科技计划重点资助项目(2004B33101010)

摘　　要：【目的】应用自行研制的骨内型牙槽骨牵张器,建立犬垂直向牙槽骨牵张成骨动物模型。【方法】实验动物为中山大学动物中心提供的健康成年杂种犬12只。实验材料为自行设计,纯钛制成的骨内型垂直向牙槽骨牵张器,体部直径3.75mm,长5mm。先拔除犬双侧下颌前磨牙,形成萎缩牙槽嵴的模型。3月后随机选取一侧行骨切开术,植入两枚牵张器。1周后开始牵张,每天1次,每次1mm,共5d;分别在牵张后1、2和3月将动物处死进行临床检查,X线检查和组织学检查。【结果】骨内型垂直牙槽骨牵张器愈合良好。牙槽骨高度平均增加(4.8±0.50)mm。组织学切片显示在牵张区有骨质形成,其骨小梁方向与牵引方向一致。【结论】采用该骨内型牙槽骨牵张器成功建立稳定的、重复性好的犬牙槽骨牵张成骨动物模型,为牙槽骨牵张器的国产化和临床上应用该项技术打下基础。[ Ohjective ] To establish an experimental dog model of vertical alveolar distraction osteogenesis using intraosseous distractors which were developed hy ourselves. [Methods] Twelve adult Mongrel dogs were providod from the Experimental Animal Center of SUN Yat-sen University. The intraosseous distractors were made in pure Ti ,which were 3.75 mm in diameter and 5 mm in length. The bilateral mandibular premolars were extracted from experimental dogs. After 3 months, an alveolar segmental osteotomy was carried out in the randomly seleetod unilateral atrophy alveolar and two intraosseous vertical alveolar distraetors were placed. After a 7-days latency period, the alveolar bone was augmented at 1.0 mm/d for five days. After a consolidation of 1, 2, and 3 months, the dogs were sacrificed for clinical, radiographic and histological examination. [Results]The intraosseous vertical alveolar distraetors obtained good healing. The atrophy alveolar were augmented for 4.8±0.50 mm. Serial histological sections showed that bone had formed in the distraction zone, where bone trabeculae formed parallel to the tension vector. [Conclusion] A stable and duplieable experimental dog model on study of vertical alveolar distraction osteogenesis have established successfully by the intraosseous distraetors, which provides a good foundation for domestic production of alveolar distraetor and clinical practice of the technique.

关 键 词：牵张成骨 牙种植 骨内 方法 疾病模型 动物 犬 

分 类 号：R782.2[医药卫生—口腔医学]