卵巢环状小管性索瘤2例报道并文献复习  

Ovarian sex cord tumor with annular tubules:a report of two cases and review of literature

作　　者：尹冬青[1] 章华元[1] 罗婉芬 张建民[3] 

机构地区：[1]台州市立医院病理科,浙江台州318000 [2]台州市第一人民医院病理科,浙江台州318020 [3]东南大学中大医院病理科,江苏南京210009

出　　处：《中华肿瘤防治杂志》2006年第15期1191-1193,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：报道2例罕见的卵巢环状小管性索瘤（SCTAT），讨论该瘤的临床病理特征。通过临床和随访资料复习、光镜组织学检查和免疫组化染色，对2例SCTAT的临床和病理学特征进行研究并复习文献。临床表现均为月经紊乱和腹部包块。病理检查2例均为单侧卵巢肿块，最大径分别为29cm和9cm，镜下肿瘤均由简单和复杂的环状小管组成，瘤细胞α-抑制素（＋），其中1例有盆腔和腹股沟淋巴结转移且于2年内复发并死亡。回顾分析显示，SCTAT在1994年1月1日～2004年12月31日我国文献（清华同方：中国医院数字图书馆、CHKD期-t1全文数据库。并列图书馆查阅及后参考文献核实病例无重复）中共有79例报道，包括我们的2例共约81例，但有Peutz—Jegher，s综合征（PJS）肿瘤仅1例，远低于国外报道。无PJS的肿瘤中约22．5％为恶性，较国外报道相近。初步研究结果显示，与PJS无关的SCTAT中约1／5有恶性生物学行为。α-抑制素是SCTAT首选的免疫标记物。Two cases of rare ovarian sex cord tumor with annular tubules （SCTAT） and to review the literature on this subject was reviewed. The clinicopathologic features of these 2 tumor cases were studied through reviewing clinical data, follow up data, and microscopic examination of histological section with routine and immunohistochemical stainings. The patients had dysmenorrhea and abdominal mass. The two tumors were 29cm and 9cm in the maximun dimension respectively, and both composed of simple and complicated annular tubules. The tumor cells of both cases showed positive staining for α inhibin. Metastases were found in pelvic（al） and inguinal lymph nodes of one case. There were 81 cases of SCTAT reported in Chinese literature. However, only one tumor reported in Chinese lit eralure was associated with Peutz Jegher＇s syndrome. Therefore, the incidence of this association is much lower in China than that abroad. The proportion of malignant tumors without Peutz-Jegher＇s syndrome was closed to the abroad. In conclusion, about one fifth of the tumors unassociated with PJS have been clinically malignant, and α-inhibin is the first choice among the immunohistochemical markers for SCTAT.

关 键 词：性索间质瘤 卵巢肿瘤 免疫组织化学 病例报告[文献类型] 

分 类 号：R737.31[医药卫生—肿瘤]