复方香黄巴布膏体外透皮吸收研究  

Transdermal absorption of Compound Xianghuang Cataplasm in vitro

作　　者：王勇[1] 贾晓斌[1] 李霞[2] 孙晶[2] 陈彦[2] 成旭东[2] 

机构地区：[1]江苏省中医药研究院 [2]江苏大学,江苏镇江210023

出　　处：《中成药》2006年第9期1254-1256,共3页Chinese Traditional Patent Medicine

基　　金：江苏省135工程重点人才资助项目(65RC2002065)

摘　　要：目的:以复方香黄巴布膏中醋酸辛酯、β-榄香烯和冰片为检测指标,研究不同浓度氮酮对该制剂体外透皮的影响。方法:利用Frans改良扩散池进行体外透皮试验,GC法测定透皮接受液中三种成分。结果:不同浓度氮酮对三种成分均有促渗作用,浓度为0、1、3和5时的加权渗透速率常数分别为0.921,2.381,3.585和2.304g.cm2/h。结论:氮酮浓度为3时促渗效果最佳,为该制剂的深入研究提供了初步依据。AIM ： To study the effects of azone at different concentration on transdermal absorption of Compound Xianghuang Cataplasm, in which acetic octyl ester, β-elemene and bomeol were determined. METHODS： Using Frans diffusion cell to conduct experiment in vitro, the three components were analyzed by GC. RESULTS： Azone at different concentration could promote the permeability of the three components, weighted penetration number were 0.921, 2. 381, 3. 585 and 2. 304 g · cm^2 · h^-1 at azone concentration of 0% , 1% , 3% and 5% respectively. CONCLUSION： 3% azone has best permeation-enhancing effect, the results are the basis for the future research on Compound Xianghuang Cataplasm.

关 键 词：复方香黄巴布膏 乙酸辛酯 β-榄香烯和冰片 GC 体外透皮吸收 

分 类 号：R944.21[医药卫生—药剂学]